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Table 1 Schistosoma mansoni histone demethylase enzymes, corresponding accessions, human orthologs comparison, structural druggability and reported inhibitors

From: The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays

Wormbase IDa size (aa)

GeneDB IDb size (aa)

Human ortholog (% ID)

UniProt ID

Structural druggabilityc

Epigenetic inhibitor/

chemical probed

Smp_150560a (1164)

LSD1 (36%)

O60341

0.752

GSK2879552, GSK-LSD1 [51]

Tranylcypromine [52]

Smp_160810a (916)

LSD2 (28%)

Q8NB78

0.589

Smp_162940a (1105)

LSD2 (27%)

Q8NB78

0.543

Smp_161400a (2575)

KDM3B (46%)

Q7LBC6

0.766

JDI‐4 [53]

Smp_132170a (984)

KDM4C (53%)

Q9H3R0

0.718

4-hydroxypyrazole [54]

Smp_019170a (1639)

KDM5D (41%)

Q9BY66

0.891

Smp_156290a (2612)

KDM5B (47%)

Q9UGL1

0.848

KDOAM-25 [55]

Smp_034000a (1393)

KDM6A (52%)

O15550

0.921

GSK-J4 [26]

Smp_315890a (483)

Smp_127230b, e

KDM7A (39%)

Q6ZMT4

0.84e

Daminozide (N-(dimethylamino) succinamic acid [56]

Smp_213920a (401)

Smp_147870b, e

JMJD4 (40%)

Q9H9V9

0.801e

Smp_316180a (782)

JMJD6 (61%)

Q6NYC1

0.857

Smp_342360a (353)

Smp_128500b, e

JMJD5 (41%)

Q8N371

0.688e

Smp_241580a (396)

Smp_180990b, e

JMJD5 (25%)

Q8N371

0.854e

Smp_333400a (771)

Smp_173670b, e

NO66/RIOX1 (26%)

Q9H6W3

0.764e

  1. aSchistosoma mansoni Wormbase ID (genome assembly version 7.0)
  2. bSchistosoma mansoni GeneDB ID (genome assembly version 5.2)
  3. cDruggability prediction with target-pathogen [30]
  4. dInhibitors described in [26, 51,52,53,54,55,56]
  5. eData obtained using contigs, containing UniProt database ID, from previous Schistosoma genome assembly (v. 5.2)