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Table 1 Schistosoma mansoni histone demethylase enzymes, corresponding accessions, human orthologs comparison, structural druggability and reported inhibitors

From: The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays

Wormbase IDa size (aa)
GeneDB IDb size (aa)
Human ortholog (% ID)
UniProt ID
Structural druggabilitycEpigenetic inhibitor/
chemical probed
Smp_150560a (1164)LSD1 (36%)
O60341
0.752GSK2879552, GSK-LSD1 [51]
Tranylcypromine [52]
Smp_160810a (916)LSD2 (28%)
Q8NB78
0.589
Smp_162940a (1105)LSD2 (27%)
Q8NB78
0.543
Smp_161400a (2575)KDM3B (46%)
Q7LBC6
0.766JDI‐4 [53]
Smp_132170a (984)KDM4C (53%)
Q9H3R0
0.7184-hydroxypyrazole [54]
Smp_019170a (1639)KDM5D (41%)
Q9BY66
0.891
Smp_156290a (2612)KDM5B (47%)
Q9UGL1
0.848KDOAM-25 [55]
Smp_034000a (1393)KDM6A (52%)
O15550
0.921GSK-J4 [26]
Smp_315890a (483)
Smp_127230b, e
KDM7A (39%)
Q6ZMT4
0.84eDaminozide (N-(dimethylamino) succinamic acid [56]
Smp_213920a (401)
Smp_147870b, e
JMJD4 (40%)
Q9H9V9
0.801e
Smp_316180a (782)JMJD6 (61%)
Q6NYC1
0.857
Smp_342360a (353)
Smp_128500b, e
JMJD5 (41%)
Q8N371
0.688e
Smp_241580a (396)
Smp_180990b, e
JMJD5 (25%)
Q8N371
0.854e
Smp_333400a (771)
Smp_173670b, e
NO66/RIOX1 (26%)
Q9H6W3
0.764e
  1. aSchistosoma mansoni Wormbase ID (genome assembly version 7.0)
  2. bSchistosoma mansoni GeneDB ID (genome assembly version 5.2)
  3. cDruggability prediction with target-pathogen [30]
  4. dInhibitors described in [26, 51,52,53,54,55,56]
  5. eData obtained using contigs, containing UniProt database ID, from previous Schistosoma genome assembly (v. 5.2)