Skip to main content

Table 1 Prevalence of polymorphisms in kelch 13 and cytochrome b genes in the analyzed falciparum isolates. K13 protein consists of a Plasmodium-specific N-terminal region (Pf N-t region), coiled-coil-containing domain (CCC), a Broad-complex, Tramtrack, Bric-a-Brac/Poxvirus and Zincfinger domain (BTB/POZ) and a C-terminal Kelch-repeat propeller domain (KREP)

From: Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol

Target gene

Codon position

Domain location

Reference sequence

Mutant sequence

Type

Allele frequency (%)

n/N

Amino acid

Nucleotide

Amino acid

Nucleotide

Pfk13

189

Pf N-t region

K

AAA

N

AAT

NS

100

4/119

189

Pf N-t region

K

AAA

T

ACA

NS

100

70/119

189

Pf N-t region

K

AAA

T

ACA

NS

43

1/119

208

Pf N-t region

E

GAA

K

AAA

NS

100

10/119

281

CCC

D

GAT

V

GTT

NS

100

2/119

401

BTB/POZ

E

GAG

Q

CAG

NS

100

4/119

622

KREP

R

AGA

I

ATA

NS

100

1/119

535

KREP

T

ACG

M

ATG

NS

20

1/119

Pfcytb

127

–

V

GTG

V

GTG

Syn

100

2/132

  1. Note: The boldface highlights the nucleotide base change
  2. Abbreviations: n, number of samples containing mutant allele; N, total number of successfully sequenced samples; NS, non-synonymous mutation