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Table 1 Prevalence of polymorphisms in kelch 13 and cytochrome b genes in the analyzed falciparum isolates. K13 protein consists of a Plasmodium-specific N-terminal region (Pf N-t region), coiled-coil-containing domain (CCC), a Broad-complex, Tramtrack, Bric-a-Brac/Poxvirus and Zincfinger domain (BTB/POZ) and a C-terminal Kelch-repeat propeller domain (KREP)

From: Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol

Target geneCodon positionDomain locationReference sequenceMutant sequenceTypeAllele frequency (%)n/N
Amino acidNucleotideAmino acidNucleotide
Pfk13189Pf N-t regionKAAANAATNS1004/119
189Pf N-t regionKAAATACANS10070/119
189Pf N-t regionKAAATACANS431/119
208Pf N-t regionEGAAKAAANS10010/119
281CCCDGATVGTTNS1002/119
401BTB/POZEGAGQCAGNS1004/119
622KREPRAGAIATANS1001/119
535KREPTACGMATGNS201/119
Pfcytb127VGTGVGTGSyn1002/132
  1. Note: The boldface highlights the nucleotide base change
  2. Abbreviations: n, number of samples containing mutant allele; N, total number of successfully sequenced samples; NS, non-synonymous mutation