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Table 5 KEGG pathways enriched in murine diaphragms between 10 and 15 dpi

From: Time-resolved transcriptional profiling of Trichinella-infected murine myocytes helps to elucidate host–pathogen interactions in the muscle stage

ID Description Gene ratio (%) Bg ratio (%) Enrich. factor q-value
ko00040 Pentose and glucuronate interconversions 3.75 0.51 7.35 0
ko00260 Glycine, serine and threonine metabolism 4.13 0.57 7.21 0
ko00983 Drug metabolism-other enzymes 4.69 0.73 6.38 0
ko04610 Complement and coagulation cascades 9.19 1.14 8.03 1.36E−31
ko00140 Steroid hormone biosynthesis 8.63 1.12 7.71 1.68E−28
ko00053 Ascorbate and aldarate metabolism 3.75 0.39 9.73 2.12E−14
ko00380 Tryptophan metabolism 3.94 0.57 6.88 1.46E−11
ko00830 Retinol metabolism 9.01 1.19 7.54 3.64E−11
ko05204 Chemical carcinogenesis 8.44 1.27 6.65 4.65E−11
ko00120 Primary bile acid biosynthesis 2.45 0.20 12.25 5.01E−11
ko00982 Drug metabolism-cytochrome P450 6.00 0.93 6.43 9.06E−11
ko00980 Metabolism of xenobiotics by cytochrome P450 5.63 0.93 6.03 9.06E−11
ko03320 PPAR signaling pathway 5.44 1.13 4.804136 1.43E−10
ko04146 Peroxisome 5.07 1.06 4.788544 6.56E−10
ko00071 Fatty acid degradation 3.75 0.66 5.688697 1.26E−08
ko00860 Porphyrin and chlorophyll metabolism 3.19 0.55 5.82445 2.38E−07
ko00591 Linoleic acid metabolism 3.38 0.65 5.22 6.13E−07
ko00590 Arachidonic acid metabolism 4.50 1.16 3.89 1.17E−06
ko00270 Cysteine and methionine metabolism 3.19 0.63 5.03 3.31E−06
ko00500 Starch and sucrose metabolism 3.38 0.76 4.45 1.07E−05
ko04976 Bile secretion 3.56 0.88 4.03 2.58E−05
ko01040 Biosynthesis of unsaturated fatty acids 2.25 0.36 6.24 3.02E−05
ko04950 Maturity onset diabetes of the young 2.06 0.32 6.38 7.86E−05
ko01230 Biosynthesis of amino acids 3.94 1.22 3.23 0.000322
ko00630 Glyoxylate and dicarboxylate metabolism 2.06 0.37 5.53 0.000435
ko00340 Histidine metabolism 1.88 0.32 5.80 0.000786
ko00220 Arginine biosynthesis 1.69 0.26 6.46 0.000854
ko00770 Pantothenate and CoA biosynthesis 1.50 0.22 6.70 0.002209
ko00350 Tyrosine metabolism 2.25 0.52 4.31 0.002898
ko00410 beta-Alanine metabolism 1.88 0.40 4.71 0.006635
  1. KEGG pathway analysis identified pathways over-represented in T. spiralis-infected mouse diaphragms (q-value < 0.01) between 10 and 15 dpi. Downregulated genes that were differentially expressed more than twofold were utilized as input. The DEGs corresponding to every enriched KEGG pathway are shown in Additional file 4: Table S4
  2. PPAR Peroxisome proliferator-activated receptor, CoA coenzyme A; for other abbreviations, see Table 4