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Table 5 KEGG pathways enriched in murine diaphragms between 10 and 15 dpi

From: Time-resolved transcriptional profiling of Trichinella-infected murine myocytes helps to elucidate host–pathogen interactions in the muscle stage

ID

Description

Gene ratio (%)

Bg ratio (%)

Enrich. factor

q-value

ko00040

Pentose and glucuronate interconversions

3.75

0.51

7.35

0

ko00260

Glycine, serine and threonine metabolism

4.13

0.57

7.21

0

ko00983

Drug metabolism-other enzymes

4.69

0.73

6.38

0

ko04610

Complement and coagulation cascades

9.19

1.14

8.03

1.36E−31

ko00140

Steroid hormone biosynthesis

8.63

1.12

7.71

1.68E−28

ko00053

Ascorbate and aldarate metabolism

3.75

0.39

9.73

2.12E−14

ko00380

Tryptophan metabolism

3.94

0.57

6.88

1.46E−11

ko00830

Retinol metabolism

9.01

1.19

7.54

3.64E−11

ko05204

Chemical carcinogenesis

8.44

1.27

6.65

4.65E−11

ko00120

Primary bile acid biosynthesis

2.45

0.20

12.25

5.01E−11

ko00982

Drug metabolism-cytochrome P450

6.00

0.93

6.43

9.06E−11

ko00980

Metabolism of xenobiotics by cytochrome P450

5.63

0.93

6.03

9.06E−11

ko03320

PPAR signaling pathway

5.44

1.13

4.804136

1.43E−10

ko04146

Peroxisome

5.07

1.06

4.788544

6.56E−10

ko00071

Fatty acid degradation

3.75

0.66

5.688697

1.26E−08

ko00860

Porphyrin and chlorophyll metabolism

3.19

0.55

5.82445

2.38E−07

ko00591

Linoleic acid metabolism

3.38

0.65

5.22

6.13E−07

ko00590

Arachidonic acid metabolism

4.50

1.16

3.89

1.17E−06

ko00270

Cysteine and methionine metabolism

3.19

0.63

5.03

3.31E−06

ko00500

Starch and sucrose metabolism

3.38

0.76

4.45

1.07E−05

ko04976

Bile secretion

3.56

0.88

4.03

2.58E−05

ko01040

Biosynthesis of unsaturated fatty acids

2.25

0.36

6.24

3.02E−05

ko04950

Maturity onset diabetes of the young

2.06

0.32

6.38

7.86E−05

ko01230

Biosynthesis of amino acids

3.94

1.22

3.23

0.000322

ko00630

Glyoxylate and dicarboxylate metabolism

2.06

0.37

5.53

0.000435

ko00340

Histidine metabolism

1.88

0.32

5.80

0.000786

ko00220

Arginine biosynthesis

1.69

0.26

6.46

0.000854

ko00770

Pantothenate and CoA biosynthesis

1.50

0.22

6.70

0.002209

ko00350

Tyrosine metabolism

2.25

0.52

4.31

0.002898

ko00410

beta-Alanine metabolism

1.88

0.40

4.71

0.006635

  1. KEGG pathway analysis identified pathways over-represented in T. spiralis-infected mouse diaphragms (q-value < 0.01) between 10 and 15 dpi. Downregulated genes that were differentially expressed more than twofold were utilized as input. The DEGs corresponding to every enriched KEGG pathway are shown in Additional file 4: Table S4
  2. PPAR Peroxisome proliferator-activated receptor, CoA coenzyme A; for other abbreviations, see Table 4
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