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Fig. 1 | Parasites & Vectors

Fig. 1

From: The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis

Fig. 1

NF-κB signalling pathway is associated with liver fibrosis in the liver tissue of mice injected with MBP-CssPLA2. a The relative mRNA levels for TNF-α of three groups of mice that received abdominal injections of 100 μg PBS, 100 μg MBP or 100 μg MBP-CssPLA2 (t(4) = 3.905, P = 0.0175). b The relative mRNA levels of IL-1β in the three groups of mice that received abdominal injections of 100 μg PBS, 100 μg MBP or 100 μg MBP-CssPLA2 (t(4) = 4.095, P = 0.0149). c The absorbance of TNF-α at 450 nm in the three groups of mice that received abdominal injections of 100 μg PBS, 100 μg MBP or 100 μg MBP-CssPLA2 (t(4) = 7.873, P = 0.0014). d The absorbance of IL-1β at 450 nm in the three groups of mice that received abdominal injections of 100 μg PBS, 100 μg MBP or 100 μg MBP-CssPLA2 (t(4) = 7.052, P = 0.0021). e Lane 1: liver tissue of a mouse injected with 100 μg MBP; lane 2: liver tissue of a mouse injected with 100 μg MBP-CssPLA2; lane 3: liver tissue of a mouse injected with PBS. f The differences in levels between the control group and the experimental group were determined by quantitation of the western blot results. Unpaired t tests were used for statistical analysis (t(4) = 4.475, P = 0.011)

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