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Fig. 7 | Parasites & Vectors

Fig. 7

From: Expression profiles of NOD-like receptors and regulation of NLRP3 inflammasome activation in Toxoplasma gondii-infected human small intestinal epithelial cells

Fig. 7

Schematic model of NLRP3 inflammasome activation in T. gondii-infected FHs 74 Int cells. T. gondii activates the p38 MAPK pathway in small intestinal epithelial cells, subsequently upregulating protein expression and promoting the formation of the NLRP3 inflammasome. The NLRP3 inflammasome cleaves pro-IL-1β, pro-IL-18 and pro-IL-33 to become active IL-1β, IL-18, and IL-33, which ultimately induces cytotoxicity of FHs 74 Int cells

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