TY - JOUR AU - Nicolas, Patricia AU - Kiuru, Caroline AU - Wagah, Martin G. AU - Muturi, Martha AU - Duthaler, Urs AU - Hammann, Felix AU - Maia, Marta AU - Chaccour, Carlos PY - 2021 DA - 2021/03/20 TI - Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study JO - Parasites & Vectors SP - 172 VL - 14 IS - 1 AB - Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. SN - 1756-3305 UR - https://doi.org/10.1186/s13071-021-04675-9 DO - 10.1186/s13071-021-04675-9 ID - Nicolas2021 ER -