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Table 1 Summary of in vitro leishmanicidal, trypanocidal and cytotoxic activity of compounds 1–3 isolated from the crude extract of Dictyota spiralis, and the Selectivity Index, compared to the positive controls miltefosine and benznidazole

From: Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis

Compound

CC50: murine macrophages (μM)

Leishmania amazonensis

Trypanosoma cruzi

IC50: promastigote (µM)

IC50: amastigote (μM)

Selectivity index

IC50: epimastigote (μM)

1

36.96 ± 2.74a

18.89 ± 5.28b

0.97 ± 0.13a

37.76

13.11 ± 3.62b

2

52.05 ± 6.63b

18.95 ± 0.42b

2.03 ± 0.22b

25.56

18.32 ± 0.91c

3

69.98 ± 0.13c

36.81 ± 5.19c

3.88 ± 0.17c

18.02

35.28 ± 4.09d

Miltefosine (positive control for Leishmania amazonensis)

72.18c

6.47 ± 0.58a

3.11c

23.16

–

Benznidazole (positive control for Trypanosoma cruzi )

400d

–

–

–

6.95a

  1. Values in table are presented as the mean ± standard deviation (SD). Means within compounds (rows) with different lowercase letters (a–d) are significantly different (P < 0.05) for each test
  2. IC50, Inhibitory concentration that inhibits 50% of the growth of the tested parasite; CC50, cytotoxic concentration that reduces 50% of the murine macrophages’ viability; Selectivity Index (SI), CC50/IC50)
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Parasites & Vectors

ISSN: 1756-3305

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