Comparative preventive efficacy of ProHeart® 12, Heartgard® Plus and Interceptor® Plus against a macrocyclic lactone-resistant strain (JYD-34) of heartworm (Dirofilaria immitis) in dogs

Table 2 Study 2: ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Design, day 165 heartworm inoculation

Group	Treatment	Dosage	Number of dogs	Day of L3 D. immitis inoculation ^a	Days of treatment	Days of blood MF and adult D. immitis AG testing	Day of necropsy and adult D. immitis worm recovery
T01	Negative control	NA	6	165	0	−14, 61, 331, 360	360 (195 days PI)
T02	ProHeart 12	0.5 mg/kg moxidectin^b	6	165	0
T03	Heartgard Plus	Min. of 6 µg/kg ivermectin ^b	6	165	0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330
T04	Interceptor Plus	Min. of 0.5 mg/kg milbemycin oxime ^b	6	165	0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330

^aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain)
^bProHeart 12, Heartgard Plus (ivermectin + pyrantel) and Interceptor Plus (milbemycin oxime + praziquantel) administered at their approved dosages according to their commercial label directions

ISSN: 1756-3305