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Table 5 Study 1: Efficacy of ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Day −30 inoculation, adult heartworm counts and percentage reductions

From: Comparative preventive efficacy of ProHeart® 12, Heartgard® Plus and Interceptor® Plus against a macrocyclic lactone-resistant strain (JYD-34) of heartworm (Dirofilaria immitis) in dogs

Treatment

Dosage

Days of treatment

Number of infected dogs a

Adult D. immitis worm counts

Efficacy compared to negative control c

Individual worm counts

Geometric mean b

Percentage reduction

Negative control

NA

0

6 of 6

23, 25, 29, 33, 35, 37

29.9g

NA

ProHeart 12

0.5 mg/kg moxidectin d

0

0 of 5

0

0h

100

Heartgard Plus

Min. of

6 µg/kg

ivermectin e

0, 30, 60, 90, 120, 150

6 of 6

19, 21, 24, 33, 34, 34

26.8g

10.5

Interceptor Plus

Min. of

0.5 mg/kg

milbemycin oxime f

0, 30, 60, 90, 120, 150

6 of 6

13, 24, 27, 30, 31, 35

25.5g

14.6

  1. aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain) on day −30
  2. bGeometric mean counts with different superscript letters are significantly different (P < 0.0001), see g, h,
  3. cAll dogs were necropsied for recovery of adult D. immitis on day 185 (215 days PI; 35 days after the last treatment with Heartgard Plus and Interceptor Plus)
  4. dProHeart 12 (moxidectin extended-release injectable suspension) administered according to commercial label directions which resulted in a point administration of 0.5 mg/kg of moxidectin to each dog. One dog in the ProHeart 12 group was euthanized on day 90 due to an abnormal health event unrelated to drug treatment
  5. eHeartgard Plus (ivermectin + pyrantel) administered according to commercial label directions which resulted in administration of from 6.6 to 11.2 µg/kg of ivermectin
  6. fInterceptor Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of from 0.52 to 1.0 mg/kg milbemycin oxime