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Table 6 Study 2: Efficacy of ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Day 165 inoculation, adult heartworm counts and percentage reductions

From: Comparative preventive efficacy of ProHeart® 12, Heartgard® Plus and Interceptor® Plus against a macrocyclic lactone-resistant strain (JYD-34) of heartworm (Dirofilaria immitis) in dogs

Treatment

Dosage

Days of treatment

Number of infected dogsa

Adult D. immitis worm counts

Efficacy compared to negative control c

Individual worm counts

Geometric meanb

Percentage reduction

Negative control

NA

0

6 of 6

27, 32, 34, 36, 37, 46

34.9g

NA

ProHeart 12

0.5 mg/kg moxidectin d

0

4 of 6

0, 0, 1, 1, 1, 1

0.6h

98.3

Heartgard Plus

Min. of

6 µg/kg

ivermectine

0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330

6 of 6

12, 20, 23, 24, 27, 29

21.7i

37.7

Interceptor Plus

Min. of

0.5 mg/kg

milbemycin oximef

0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330

6 of 6

14, 19, 23, 24, 25, 37

22.7i

34.9

  1. aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain) on day 165
  2. bGeometric mean counts with different superscript letters are significantly different (P ≤ 0.0321), see g, h, i
  3. cAll dogs were necropsied for recovery of adult D. immitis on day 360 (195 days PI; 30 days after the last treatment with Heartgard Plus and Interceptor Plus)
  4. dProHeart 12 (moxidectin extended-release injectable suspension) administered according to commercial label directions which resulted in a point administration of 0.5 mg/kg of moxidectin to each dog
  5. eHeartgard Plus (ivermectin + pyrantel) administered according to commercial label directions which resulted in administration of 6.5 to 11.5 µg/kg of ivermectin
  6. fInterceptor Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of 0.51 to 1.1 mg/kg milbemycin oxime