Table 1 Sensitivity and specificity of diagnostic tests in 100 stray adult dogs in Florida animal shelters compared to heartworm antigen (Ag) detection in (a) non-heat-treated serum and (b) heat-treated serum
From: Optimizing heartworm diagnosis in dogs using multiple test combinations
Tests | Sensitivity (%) | Sensitivity 95% CI (%) | Specificity (%) | Specificity 95% CI (%) | Total positive results (n) | False-negative results (n) | False-positive results (n) |
|---|---|---|---|---|---|---|---|
a. Test operating characteristics compared to non-heat-treated serum with the DiroCHEK® Antigen test. A total of 16 dogs had positive results with non-heat-treated serum | |||||||
 WITNESS® HW Ag | 88 | 62–98 | 100 | 96–100 | 14 | 2 | 0 |
 SNAP® Ag | 88 | 62–98 | 100 | 96–100 | 14 | 2 | 0 |
 DiroCHEK® Ag (heat treated) | 100 | 79–100 | 86 | 76–92 | 28 | 0 | 12 |
 HESKA Solostep® FH (Ab) | 69 | 41–89 | 76 | 66–85 | 31 | 5 | 20 |
 Antech heartworm antibody test | 56 | 30–80 | 90 | 82–96 | 17 | 7 | 8 |
b. Test operating characteristics compared to heat-treated serum with the DiroCHEK® Antigen test. A total of 28 dogs had positive results with heat-treated serum | |||||||
 WITNESS® HW Ag | 50 | 31–69 | 100 | 95–100 | 14 | 14 | 0 |
 SNAP® Ag | 50 | 31–69 | 100 | 95–100 | 14 | 14 | 0 |
 DiroCHEK® Ag (non-heat treated) | 57 | 37–76 | 100 | 95–100 | 16 | 12 | 0 |
 HESKA Solostep® FH (Ab) | 64 | 44–81 | 82 | 71–90 | 31 | 10 | 13 |
 Antech heartworm antibody test | 46 | 28–66 | 94 | 86–98 | 17 | 15 | 4 |