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Table 1 Baseline characteristics of patients enrolled in this study

From: Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis

Characteristic

Healthy control group (n = 18)

SHF stage F2 groupa (n = 18)

t-test (n = 18)b

P*

SHF stage F4 groupa (n = 18)

t-test (n = 18)c

P§

Gender (female/male)

9/9

8/10

N/A

N/A

10/8

N/A

N/A

Age (years)

74.83 ± 6.11

74.94 ± 6.73

− 0.052

0.959

75.00 ± 5.48

− 0.270

0.978

ALT (U/l)

13.72 ± 3.34

17.17 ± 5.32

− 2.328

0.026

35.89 ± 4.59§

− 11.312

< 0.001

AST (U/L)

18.44 ± 4.02

32.50 ± 7.34*

− 7.125

< 0.001

47.78 ± 9.52§

− 5.391

< 0.001

ALP (U/l)

29.11 ± 7.11

85.44 ± 15.89*

− 13.725

< 0.001

150.40 ± 42.11§

− 6.112

< 0.001

GGT (U/l)

21.39 ± 7.51

32.56 ± 19.25

− 2.292

0.032

146.39 ± 125.98§

− 3.789

0.001

PLT (109 l−1)

220.61 ± 41.52

92.33 ± 17.99*

12.027

< 0.001

42.83 ± 19.78§

7.855

< 0.001

TB (umol/l)

6.34 ± 1.49

15.67 ± 4.03*

− 9.203

< 0.001

29.59 ± 14.95§

− 3.816

0.001

TBA (umol/l)

2.78 ± 1.40

3.88 ± 2.28

− 1.734

0.092

25.69 ± 14.50§

− 6.304

< 0.001

Albumin (g/l)

48.32 ± 3.23

47.59 ± 2.53

0.747

0.461

39.46 ± 2.83§

9.101

< 0.001

APRI

0.67 ± 0.18

2.73 ± 0.48*

− 16.921

< 0.001

10.15 ± 4.76§

− 6.584

< 0.001

PT (s)

N/A

12.89 ± 0.62

N/A

N/A

15.52 ± 1.27§

− 7.906

< 0.001

INR

N/A

1.00 ± 0.05

N/A

N/A

1.20 ± 0.10§

− 7.821

< 0.001

APTT (s)

N/A

37.27 ± 3.23

N/A

N/A

42.31 ± 3.09§

− 4.786

< 0.001

FIB (g/l)

N/A

2.95 ± 0.58

N/A

N/A

2.32 ± 0.43§

3.696

0.001

  1. Values in table are present as the mean ± standard deviation
  2. ALP Alkaline phosphatase, ALT alanine aminotransferase, APRI AST-to-PLT ratio index, APTT activated partial thromboplastin, AST aspartate aminotransferase, FIB fibrinogen content, GGT gamma-glutamyltranspeptidase, INR international normalized ratio, N/A information not available, PLT platelet count, SHF schistosomiasis-induced hepatic fibrosis, PT prothrombin time, TB total bilirubin, TBA total bile acid
  3. *P value < 0.05 for comparisons between patients with SHF stage F2 and healthy controls, and §P value < 0.05 for comparisons between patients with SHF stage F4 and and those with SHF stage F2.
  4. aSHF was staged from F0 to F4 according the METAVIR scoring system
  5. bStudent’s t-test for comparisons between patients with SHF stage F2 and healthy controls
  6. cStudent’s t-test for comparisons between patients with SHF stage F4 and those with SHF stage F2