Skip to main content

Table 1 Evaluation of the transmission-blocking activity of different immunization groups in mosquito feeding assays

From: Evaluation of two sexual-stage antigens as bivalent transmission-blocking vaccines in rodent malaria

Mouse Immunization group Oocyst density mean (range)
(n = 180)
TRAa Prevalence of infection mean (n = 180) TBAb
Mouse 1–6 Control 130.6 (0–254)   94.4% (170/180)  
Trx-His 129.4 (0–254)   95.6% (172/180)  
Pbg37 66.8 (0–224) 48.4% 92.2% (166/180) 3.4%
PSOP25 48.7 (0–167) 62.3% 82.8% (149/180) 12.8%
Pbg37+PSOP25 32.4 (0–138) 74.9% 80.0% (144/180) 15.6%
Pbg37-PSOP25 29.7 (0–140) 77.0% 76.1% (137/180) 19.5%
  1. aTRA was calculated as (mean oocyst densityTrx-His – mean oocyst density Pbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25) / mean oocyst densityTrx-His × 100%
  2. b TBA was calculated as % prevalenceTrx-His – % prevalencePbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25