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Table 1 Evaluation of the transmission-blocking activity of different immunization groups in mosquito feeding assays

From: Evaluation of two sexual-stage antigens as bivalent transmission-blocking vaccines in rodent malaria

Mouse

Immunization group

Oocyst density mean (range)

(n = 180)

TRAa

Prevalence of infection mean (n = 180)

TBAb

Mouse 1–6

Control

130.6 (0–254)

 

94.4% (170/180)

 

Trx-His

129.4 (0–254)

 

95.6% (172/180)

 

Pbg37

66.8 (0–224)

48.4%

92.2% (166/180)

3.4%

PSOP25

48.7 (0–167)

62.3%

82.8% (149/180)

12.8%

Pbg37+PSOP25

32.4 (0–138)

74.9%

80.0% (144/180)

15.6%

Pbg37-PSOP25

29.7 (0–140)

77.0%

76.1% (137/180)

19.5%

  1. aTRA was calculated as (mean oocyst densityTrx-His – mean oocyst density Pbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25) / mean oocyst densityTrx-His × 100%
  2. b TBA was calculated as % prevalenceTrx-His – % prevalencePbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25