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Table 1 Half maximal inhibitory concentrations of Daniellia oliveri and Psorospermum febrifugum plant extracts for Onchocerca ochengi and Brugia pahangi

From: Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts

Extracts O. ochengi B. pahangi
IC50 microfilariae (µg/ml)a IC50 adult worm (µg/ml)a IC50 adult worm (µg/ml)a
DOLHEX Inactive Inactive 89.8 ± 1.3
DOLDCMb 16.2 ± 0.0 43.3 ± 9.2 6.1 ± 1.3
DOLMeOH Inactive Inactive 81.9 ± 1.2
DOBHEXb 185.2 ± 0.0 13.9 ± 1.7 59.0 ± 1.2
DOBDCMb 9.7 ± 0.0 22.5 ± 0.0 6.3 ± 1.2
DOBMeOH Inactive Inactive 44.0 ± 1.3
PFLHEX Inactive Inactive 153.7 ± 1.5
PFLDCM 132.4 ± 0.0 Inactive Yet to be determined
PFLMeOH 8.8 ± 0.0 Inactive Inactive
PFBHEX 4 ± 0.0 Inactive Yet to be determined
PFBDCM 7.2 ± 0.0 Inactive Yet to be determined
PFBMeOH 6.6 ± 0.0 Inactive Yet to be determined
  1. DO Daniellia oliveri, PF Psorospermum febrifugum; HEX hexane, DCM dichloromethane, MeOH methanol
  2. aHalf maximal inhibitory concentration (IC50) is given as the mean ± standard error of the mean
  3. bExtracts DOBHEX, DOLDCM and DOBDCM were the only plant extracts of the 12 active extracts identified which were active in all three biological assays used in this study (O. ochengi microfilariae, adult O. ochengi or adult B. pahang)