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Table 1 Half maximal inhibitory concentrations of Daniellia oliveri and Psorospermum febrifugum plant extracts for Onchocerca ochengi and Brugia pahangi

From: Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts

Extracts

O. ochengi

B. pahangi

IC50 microfilariae (µg/ml)a

IC50 adult worm (µg/ml)a

IC50 adult worm (µg/ml)a

DOLHEX

Inactive

Inactive

89.8 ± 1.3

DOLDCMb

16.2 ± 0.0

43.3 ± 9.2

6.1 ± 1.3

DOLMeOH

Inactive

Inactive

81.9 ± 1.2

DOBHEXb

185.2 ± 0.0

13.9 ± 1.7

59.0 ± 1.2

DOBDCMb

9.7 ± 0.0

22.5 ± 0.0

6.3 ± 1.2

DOBMeOH

Inactive

Inactive

44.0 ± 1.3

PFLHEX

Inactive

Inactive

153.7 ± 1.5

PFLDCM

132.4 ± 0.0

Inactive

Yet to be determined

PFLMeOH

8.8 ± 0.0

Inactive

Inactive

PFBHEX

4 ± 0.0

Inactive

Yet to be determined

PFBDCM

7.2 ± 0.0

Inactive

Yet to be determined

PFBMeOH

6.6 ± 0.0

Inactive

Yet to be determined

  1. DO Daniellia oliveri, PF Psorospermum febrifugum; HEX hexane, DCM dichloromethane, MeOH methanol
  2. aHalf maximal inhibitory concentration (IC50) is given as the mean ± standard error of the mean
  3. bExtracts DOBHEX, DOLDCM and DOBDCM were the only plant extracts of the 12 active extracts identified which were active in all three biological assays used in this study (O. ochengi microfilariae, adult O. ochengi or adult B. pahang)
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Parasites & Vectors

ISSN: 1756-3305

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