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Table 2 Selectivity index values of active extracts of D. oliveri and P. febrifugum

From: Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts

Extracts IC50 N27 cells (µg/ml) O. ochengi B. pahangi
Microfilariae Adult Adult
IC50 (µg/ml) SIa IC50 (µg/ml) SIa IC50 (µg/ml) SIa
DOLHEX Tbd Inactive / Inactive tbd 89.8 /
DOLDCMb 222.8 16.2 13.8 43.3 5.1 6.1 36.5
DOLMeOH Tbd Inactive / Inactive / 81.9 /
DOBHEXb  > 250 185.2  > 1.3 13.9  > 18.0 59.0  > 4.2
DOBDCMb 224.6 9.7 23.2 22.5 10.0 6.3 35.7
DOBMeOH / Inactive / Inactive / 44.0 /
PFLHEX / Inactive / Inactive / 153.7 /
PFLDCM 35.1 132.4 0.3 Inactive /  < 300 /
PFLMeOH 331.1 8.8 37.6 Inactive / Inactive /
PFBHEX 47.0 4 11.8 Inactive /  < 300 /
PFBDCM  > 250 7.2  > 34.7 Inactive /  < 300 /
PFBMeOH 98.2 6.6 14.9 Inactive /  < 300 /
  1. aSelectivity index (SI) is calculated as IC50 N27 cells/IC50 parasite
  2. bExtracts DOBHEX, DOLDCM and DOBDCM were the only plant extracts of the 12 active extracts identified which were active in all three biological assays used in this study (O. ochengi microfilariae, adult O. ochengi or adult B. pahang). Tbd To be determined