Table 2 Selectivity index values of active extracts of D. oliveri and P. febrifugum
From: Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts
Extracts | IC50 N27 cells (µg/ml) | O. ochengi | B. pahangi | ||||
|---|---|---|---|---|---|---|---|
Microfilariae | Adult | Adult | |||||
IC50 (µg/ml) | SIa | IC50 (µg/ml) | SIa | IC50 (µg/ml) | SIa | ||
DOLHEX | Tbd | Inactive | / | Inactive | tbd | 89.8 | / |
DOLDCMb | 222.8 | 16.2 | 13.8 | 43.3 | 5.1 | 6.1 | 36.5 |
DOLMeOH | Tbd | Inactive | / | Inactive | / | 81.9 | / |
DOBHEXb |  > 250 | 185.2 |  > 1.3 | 13.9 |  > 18.0 | 59.0 |  > 4.2 |
DOBDCMb | 224.6 | 9.7 | 23.2 | 22.5 | 10.0 | 6.3 | 35.7 |
DOBMeOH | / | Inactive | / | Inactive | / | 44.0 | / |
PFLHEX | / | Inactive | / | Inactive | / | 153.7 | / |
PFLDCM | 35.1 | 132.4 | 0.3 | Inactive | / |  < 300 | / |
PFLMeOH | 331.1 | 8.8 | 37.6 | Inactive | / | Inactive | / |
PFBHEX | 47.0 | 4 | 11.8 | Inactive | / |  < 300 | / |
PFBDCM |  > 250 | 7.2 |  > 34.7 | Inactive | / |  < 300 | / |
PFBMeOH | 98.2 | 6.6 | 14.9 | Inactive | / |  < 300 | / |