Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs

Table 1 Dosing scheme utilized in the adult and juvenile target animal safety studies

Dose level	Dose administration study days
Dose level	0, 28, 56, 84, 112, 140, 168, 196^, 224^	1, 29, 57, 85, 113, 141, 169, 197^, 225^	2, 30, 58, 86, 114, 142, 170, 198^, 226^	3, 31, 59, 87, 115, 143, 171, 199^, 227^	4, 32, 60, 88, 116, 144, 172, 200^, 228^
0X	Placebo	Placebo	Placebo	Placebo	Placebo
1X	Placebo	Placebo	Placebo	Placebo	1X
3X	Placebo	Placebo	1X	1X	1X
5X	1X	1X	1X	1X	1X

ISSN: 1756-3305