Study | Dose level | Mean lotilaner dose (mg/kg) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Dose cycle 1 | Dose cycle 2 | Dose cycle 3 | Dose cycle 4 | Dose cycle 5 | Dose cycle 6 | Dose cycle 7 | Dose cycle 8 | Dose cycle 9 | ||
Adult | 1X | 35.9 | 33.9 | 36.9 | 35.7 | 35.1 | 36.3 | 35.8 | N/A | N/A |
3X | 109.7 | 107.5 | 106.4 | 107.3 | 110.5 | 107.7 | 108.4 | N/A | N/A | |
5X | 179.7 | 177.8 | 184.1 | 179.7 | 181.9 | 179.5 | 179.4 | N/A | N/A | |
Juvenile | 1X | 44.5 | 35.2 | 35.1 | 34.5 | 35.8 | 34.8 | 35.1 | 36.7 | 34.6 |
3X | 118.9 | 110.6 | 109.9 | 101.4 | 104.9 | 112.1 | 105.4 | 110.9 | 108.5 | |
5X | 199.5 | 177.6 | 180.1 | 178.8 | 180.1 | 178.0 | 172.9 | 176.0 | 176.0 |