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Table 3 Mean monthly lotilaner dose (mg/kg) received in the adult and juvenile target animal safety studies

From: Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs

Study

Dose level

Mean lotilaner dose (mg/kg)

Dose cycle 1

Dose cycle 2

Dose cycle 3

Dose cycle 4

Dose cycle 5

Dose cycle 6

Dose cycle 7

Dose cycle 8

Dose cycle 9

Adult

1X

35.9

33.9

36.9

35.7

35.1

36.3

35.8

N/A

N/A

3X

109.7

107.5

106.4

107.3

110.5

107.7

108.4

N/A

N/A

5X

179.7

177.8

184.1

179.7

181.9

179.5

179.4

N/A

N/A

Juvenile

1X

44.5

35.2

35.1

34.5

35.8

34.8

35.1

36.7

34.6

3X

118.9

110.6

109.9

101.4

104.9

112.1

105.4

110.9

108.5

5X

199.5

177.6

180.1

178.8

180.1

178.0

172.9

176.0

176.0

  1. N/A: Not applicable