|
Study
|
Stage at time of treatment
|
Day of inoculation a
|
Day of treatment
|
Day of necropsy (worm recovery)
|
Treatment group
|
n
|
No. of infected dogs
|
Worm count range
|
Geometric worm count
|
Effectiveness compared to vehicle control
|
|---|
|
% efficacy
|
Effectiveness P-value
|
|---|
|
1
|
L4 Larvae
|
0
|
7
|
12
|
Vehicle control
|
8
|
8
|
60–248
|
171.9
|
–
|
–
|
| | | | | |
Credelio Plusb
|
8
|
8
|
1–15
|
4.6
|
97.3
|
P < 0.001
|
| | | | | |
Credelioc
|
8
|
8
|
98–236
|
171.7
|
0.1
|
P < 0.001
|
|
2
|
L4 Larvae
|
0
|
7
|
12
|
Vehicle control
|
10
|
10
|
42–156
|
79.4
|
–
|
–
|
| | | | | |
Credelio Plusb
|
10
|
3
|
0–2
|
0.3
|
99.6
|
P < 0.001
|
|
1
|
Immature adult (L5)
|
0
|
11
|
16
|
Vehicle control
|
8
|
8
|
173–255
|
198.7
|
–
|
–
|
| | | | | |
Credelio Plusb
|
8
|
6
|
0–86
|
2.5
|
98.7
|
P < 0.001
|
| | | | | |
Credelioc
|
8
|
8
|
149–231
|
178.8
|
10.0
|
P < 0.001
|
|
2
|
Immature adult (L5)
|
0
|
11
|
16
|
Vehicle control
|
10
|
10
|
61–302
|
109.7
|
–
|
–
|
| | | | | |
Credelio Plusb
|
10
|
2
|
0–3
|
0.3
|
99.7
|
P < 0.001
|
- n Number of animals per group
- aEach dog was inoculated with ca. 300 L3 A. caninum
- bCredelio Plus provided minimum dosages of 0.845 to 0.943 mg/kg of milbemycin oxime in both studies
- cCredelio™ (lotilaner mono product) was included in study 1 to assess non-interference
