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Table 5 The proportion of each 2-dose interval with and without ectoparasite protection

From: Analysis of gaps in feline ectoparasiticide purchases from veterinary clinics in the United States

Product Fluralaner topical Fipronil/(s)-methoprene/pyriproxyfen Imidacloprid/pyriproxyfen Selamectin
  Doses plus gap perioda
(weeks)
% of time protected % of time not protected Period of coveragea
(weeks)
% of time protected % of time not protected Period of coveragea
(weeks)
% of time protected % of time not protected Period of coveragea
(weeks)
% of time protected % of time not protected
Dose period    
Dose 1–2 35.2 68 32 22.5 38 62 21.9 39 61 21.5 40 60
Dose 2–3 31.7 76 24 20.8 41 59 18.6 46 54 18.8 46 54
Dose 3–4 28.5 84 16 21.3 40 60 18.8 46 54 18.8 46 54
Dose 4–5 26.5 91 9 18.7 46 54 19.7 44 56 16.8 51 49
Dose 5–6     15.2 57 43 14.3 60 40 14.2 61 39
Dose 6–7     18.6 46 54 17.6 49 51 17.7 49 51
Dose 7–8     14.5 59 41 11.6 74 26 12.9 67 33
Dose 8–9     14.8 58 42 11.9 72 28 14.0 61 39
Dose 9–10     14.2 61 39 14.2 61 39 13.0 66 34
Dose 10–11     12.4 69 31 10.9 79 21 11.8 73 27
Dose 11–12     10.6 81 19 9.6 90 10 11.3 76 24
  1. a“Doses plus gap period” is the time from the administration of one dose through the end of the treatment period of the subsequent dose, including the dosing gap, measured in weeks. For Fipronil/(s)-methoprene/pyriproxyfen , imidacloprid/pyriproxyfen and selamectin, the single dose duration of efficacy was 4.3 weeks. For fluralaner topical the single dose duration of efficacy was 12 weeks per label indication (Note: Up to 7 doses of fluralaner may be required for full year protection in areas where Dermacentor variabilis are of concern)