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Table 4 Frequency of pancreatic histological changes according to the result of IHC for the detection of Leishmania spp. amastigote forms in 143 dogs from the town of Barra Mansa, Rio de Janeiro, Brazil (2012 to 2013)

From: Frequency of detection and load of amastigotes in the pancreas of Leishmania infantum-seropositive dogs: clinical signs and histological changes

Histological changes

IHC for detection of Leishmania amastigotes

p value

Negative (N = 121)

Positive (N = 22)

n

%

95% CI (%)

n

%

95% CI (%)

Granulomatous pancreatitis

23

19.0

12.4–27.1

17

77.3

54.6–92.2

0.007a

Lymphoplasmacytic pancreatitis

31

25.6

18.1–34.3

3

13.6

2.9–34.9

0.004a

Vacuolar degeneration of acinar cells

6

5.0

1.8–10.5

1

4.5

0.1–22.8

1.000

Fibrosis

4

3.3

0.9–8.2

2

9.1

1.1–29.5

0.248

Hemorrhage

2

1.6

0.2–7.4

1

4.5

0.1–22.8

1.000

Eosinophilic pancreatitis

1

0.8

0.0–4.5

0

0

_b

Suppurative pancreatitis

1

0.8

0.0–4.5

0

0

_b

Necrosis

1

0.8

0.0–4.5

0

0

_b

Absence of histological changes

61

50.4

41.2–59.6

2

9.1

1.1–29.2

0.009a

  1. N number of dogs, n number of samples, IHC immunohistochemistry, 95% CI 95% confidence interval
  2. aStatistically significant difference at the 5% level
  3. bStatistical analysis was not possible because of the absence of the histological change in one of the groups