A strong effect of individual compliance with mass drug administration for lymphatic filariasis on sustained clearance of soil-transmitted helminth infections

Table 1 Sustained clearance rates for hookworm, Ascaris and Trichuris infections

Variables	Categories	Hookworm (202 individuals)					Ascaris (211 individuals)					Trichuris (270 individuals)
Variables	Categories	PY	No. of events	Rate^a	95% CI	P	PY	No. of events	Rate^a	95% CI	P	PY	No. of events	Rate^a	95% CI	P
	All participants	701	135	19.2	16.2–22.8		681	172	25.2	21.7–29.3		1019	86	8.4	6.8–10.4
Sex	Male	390	69	17.7	14.0–22.4	0.023	299	63	21.1	16.5–27.0	0.017	420	36	8.6	6.2–11.9	0.919
Sex	Female	311	66	21.2	16.7–27.9	0.023	382	109	28.5	23.7–34.4		599	50	8.3	6.3–11.0
Age	5–8 Years	245	30	12.2	8.6–17.5	0.009	153	20	13.1	8.4–20.3	0.001	201	7	3.5	1.7–7.3	< 0.001
	8–12 Years	166	39	23.5	17.2–32.2		189	46	24.3	18.2–32.5		222	9	4.0	2.1–7.8
	13–30 Years	135	24	17.8	11.9–26.5		117	32	27.3	19.3–38.7		209	16	7.6	4.7–12.5
	≥ 31 Years and more	155	42	27.1	20.0–36.6		222	74	33.3	26.5–41.9		387	54	13.9	10.7–18.2
Initial infection intensity^b	Light	575	131	20.0	16.8–23.7	0.059	269	77	28.6	22.9–35.8	0.022	634	74	11.7	9.3–14.7	< 0.001
	Moderate	29	4	13.8	5.2–36.5		374	87	23.3	18.8–28.7		369	11	3.0	1.6–5.4
	Heavy	16	0	0	N/A		38	8	21.0	10.5–42.1		16	1	6.2	0.9–44.4
Village	Misay	323	61	18.9	14.7–24.3	0.001	44	8	18.2	9.1–36.3	0.247	3	1	N/A	N/A
	Mbunkimi	336	56	16.7	12.8–21.6		41	13	31.7	18.4–54.6		20	4	N/A	N/A
	Seke Pembe	42	18	42.8	27.0–68.0		596	151	25.3	21.6–29.7		994	80	8.0	6.5–10.0

P is calculated from significance tests using the Mantel–Haenszel method based on stratified rate ratios
PY Person-years, CI confidence interval
^aInfection status conversion rate (for 100 PY)
^bAccording to World Health Organization (WHO) guidelines: for hookworm, 1–1999 (light), 2000–3999 (moderate), > 4000 eggs per gram of stool (EPG) (heavy); for Ascaris, 1–4999 (light), 5000–49,999 (moderate), > 49,999 EPG (heavy); for Trichuris, 1–999 (light), 1000–9999 (moderate), > 10,000 EPG (heavy)

ISSN: 1756-3305