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Table 4 Mixed model results for the evolution of EPG intensity

From: A strong effect of individual compliance with mass drug administration for lymphatic filariasis on sustained clearance of soil-transmitted helminth infections

Variables

Categories

Hookworm

Ascaris

Trichuris

Coeff./95% CIa

P

Coeff./95% CIa

P

Coeff./95% CIa

P

Sex

Female

Ref.

 

Ref.

 

Ref.

 

Male

65.8 (− 34.4, 166.0)

0.199

1056.7 (− 1115.9, 3229.2)

0.340

234.2 (− 139.1, 607.5)

0.219

Age

5–8 Years

Ref.

 

Ref.

 

Ref.

 

8–12 Years

32.6 (− 122.6, 187.8)

0.681

− 4540.2 (− 7576.5,  − 1504.0)

0.003

126.1 (− 439.3,  691.6)

0.662

13–30 Years

− 128.0 (− 274.1, 18.0)

0.086

− 6432.5( − 9910.3,  − 2954.8)

0.0001

− 333.9 ( − 929.6,  261.7)

0.272

More than 30 years

− 107.1 (− 251.4, 37.1)

0.088

− 8030.3 (− 11035,  − 5024.5)

 < 0.001

− 498.6 (− 1179.8,  − 162.3)

0.010

Initial infection intensityb

Light

Ref.

 

Ref.

 

Ref.

 

Moderate

1155.4 (929.3, 1383, 5)

 < 0.001

8727.8 (6302.6,  11153)

 < 0.001

1061.2 (653.1,  1469.4)

 < 0.001

Heavy

3171.6 (2875.8, 3467.3)

 < 0.001

33, 843 (28637,  39050)

 < 0.001

6886.7 (5518.5,  8254.9)

 < 0.001

Timec

Continuous

− 58.2 (− 263.2, 146.6)

0.577

1631.5 (− 4174.5,  7437.4)

0.582

− 91.9 (− 378.8,  195.0)

0.530

Annual treatment interaction with timec

Zero doses

Ref.

 

Ref.

 

Not calculable

 

One dose

− 81.2 (− 316.0, 153.6)

0.498

− 7076.1 (− 13,103,  − 1048.9)

0.021

Ref.

 

Two doses

− 197.1 (− 402.6, 8.4)

0.060

− 6207.3 (− 12,196,  − 218.5)

0.042

− 207.5 (− 603.2,  188.3)

0.304

Study site

Bandundu

Ref.

 

Ref.

 

Ref.

 

Seke Pembe

− 196.9 (− 427.8, 34.0)

0.095

2596.8 (− 1004.8,  6198.3)

0.158

721.0 (− 410.1,  1852.1)

0.212

Intercept at baseline

Zero doses

387.4 (− 478.5, 1253.2)

0.381

− 7884 − 33,495,  17,725.7)

0.546

Not calculable

 

One dose

272.7 (− 636.0, 1181.4)

0.556

22,598 (− 3365.0,  48,561)

0.088

− 199.5 (− 170.9,  1305.9)

0.795

Two doses

404.0 (− 439.6, 1247.7)

0.348

22,888 (− 2750.4,  48,527)

0.080

936.6 (− 192.0,  2065.1)

0.104

  1. aAdjusted regression coefficient (Coeff.)/95% CI
  2. bAccording to WHO guidelines: for hookworm, 1–1999 (light), 2000–3999 (moderate), > 4000 EPG (heavy); for Ascaris, 1–4999 (light), 5000–49,999 (moderate), > 49,999 EPG (heavy); for Trichuris, 1–999 (light), 1000–9999 (moderate), > 10,000 EPG (heavy)
  3. cInterpretation of the interaction variable: for the hookworm model, all else being equal, each participant’s EPG decreased by 58.2 each year; and all else being equal, participants taking one dose and two doses per year, as compared to zero doses, showed a decrease in their EPG by 81.2 and 197.1 EPG per year, respectively