Table 1 Clinical manifestations, gender, age at onset of clinical signs, serology, polymerase chain reaction (PCR), laboratory abnormalities, therapy and response to therapy among individual dogs of a cluster of canine leishmaniosis caused by Leishmania infantum
From: Early onset of clinical leishmaniosis in a litter of pups with evidence of in utero transmission
Dog identity | Gender | Clinical signs | Age of onset of clinical signs in months | ELISA serology | PCR positivity and locia | PCR-positive tissue | Hematological and biochemical changes | Treatment | Response to treatment |
|---|---|---|---|---|---|---|---|---|---|
Puppy 1 | Female | Nasal, truncal and pinnal crusty exfoliative dermatitis; peripheral lymphadenomegaly; keratoconjunctivitis; fever; right hind limb lameness | 2 | Positive | kDNA, ITS1 | Â | Leukocytosis; hyperproteinemia; hypergammaglobulinemia; increased liver enzymes; normochromic, normocytic anemia | Allopurinol | Clinical remission within 3Â months |
Puppy 2 | Female | Nasal alopecia and mild exfoliative periocular dermatitis | 2.5 | Positive | kDNA, ITS1 | Lymph node, blood, conj. Lymph node, blood | No abnormalities | Allopurinol | Clinical remission within 3Â months |
Puppy 3 | Male | Pinnal and periocular exfoliative dermatitis | 2.5 | Positive | kDNA | Blood, conj. | No abnormalities | Allopurinol | Clinical remission within 3Â months |
Puppy 4 | Female | Localized alopecia of nasal planum | 2.5 | Negative | ITS1 | Conj. | No abnormalities | Allopurinol | Clinical remission within 3Â months |
Puppy 5 | Male | Localized nasal ulcer; diarrhea and vomiting; conjunctivitis | 2.5 | Positive | kDNA, ITS1 | Lymph node, conj. | Hypergammaglobulinemia | Allopurinol | Clinical remission within 3Â months |
Puppy 6 | Male | Pinnal alopecia | 3.5 | Positive | kDNA, ITS1 | Lymph node, blood, conj. | Hyperproteinemia; hypergammaglobulinemia | Allopurinol | Clinical remission within 3Â months |
Puppy 7 | Male | Cutaneous nasal planum ulcer | 6 | Negative | kDNA, ITS1 | Skin | No abnormalities | Allopurinol | Clinical remission within 3Â months |
Puppy 8 | Female | Â | Â | Negative | kDNA, ITS1 | Blood, conj. | No abnormalities | Â | Â |
Puppy 9 | Male | Â | Â | Negative | kDNA, ITS1 | Conj. | No abnormalities | Â | Â |
Sire | Male | Exfoliative dermatitis; keratoconjunctivitis; weight loss, weakness | 25 | Positive | kDNA | Lymph node, semen | Not performed | Allopurinol | Clinical remission within 3Â months |
Dam | Female | Â | Â | Negative | kDNA, ITS1 | Lymph node, blood, conj. | No abnormalities | Â | Â |