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Table 1 Clinical manifestations, gender, age at onset of clinical signs, serology, polymerase chain reaction (PCR), laboratory abnormalities, therapy and response to therapy among individual dogs of a cluster of canine leishmaniosis caused by Leishmania infantum

From: Early onset of clinical leishmaniosis in a litter of pups with evidence of in utero transmission

Dog identity Gender Clinical signs Age of onset of clinical signs in months ELISA serology PCR positivity and locia PCR-positive tissue Hematological and biochemical changes Treatment Response to treatment
Puppy 1 Female Nasal, truncal and pinnal crusty exfoliative dermatitis; peripheral lymphadenomegaly; keratoconjunctivitis; fever; right hind limb lameness 2 Positive kDNA, ITS1   Leukocytosis; hyperproteinemia; hypergammaglobulinemia; increased liver enzymes; normochromic, normocytic anemia Allopurinol Clinical remission within 3 months
Puppy 2 Female Nasal alopecia and mild exfoliative periocular dermatitis 2.5 Positive kDNA, ITS1 Lymph node, blood, conj.
Lymph node, blood
No abnormalities Allopurinol Clinical remission within 3 months
Puppy 3 Male Pinnal and periocular exfoliative dermatitis 2.5 Positive kDNA Blood, conj. No abnormalities Allopurinol Clinical remission within 3 months
Puppy 4 Female Localized alopecia of nasal planum 2.5 Negative ITS1 Conj. No abnormalities Allopurinol Clinical remission within 3 months
Puppy 5 Male Localized nasal ulcer; diarrhea and vomiting; conjunctivitis 2.5 Positive kDNA, ITS1 Lymph node, conj. Hypergammaglobulinemia Allopurinol Clinical remission within 3 months
Puppy 6 Male Pinnal alopecia 3.5 Positive kDNA, ITS1 Lymph node, blood, conj. Hyperproteinemia; hypergammaglobulinemia Allopurinol Clinical remission within 3 months
Puppy 7 Male Cutaneous nasal planum ulcer 6 Negative kDNA, ITS1 Skin No abnormalities Allopurinol Clinical remission within 3 months
Puppy 8 Female    Negative kDNA, ITS1 Blood, conj. No abnormalities   
Puppy 9 Male    Negative kDNA, ITS1 Conj. No abnormalities   
Sire Male Exfoliative dermatitis; keratoconjunctivitis; weight loss, weakness 25 Positive kDNA Lymph node, semen Not performed Allopurinol Clinical remission within 3 months
Dam Female    Negative kDNA, ITS1 Lymph node, blood, conj. No abnormalities   
  1. ELISA Enzyme-linked immunosorbent assay, conj. conjunctival swab
  2. aTargeted loci found to be PCR positive; PCR targeting the Leishmania kinetoplast minicircle (kDNA); Leishmania ribosomal operon internal transcribed spacer 1 (ITS1) region