Table 3 Potential serum biomarkers response to C. baileyi infection in chickens based on receiver operating characteristic curve analysis
From: Serum metabolomics in chickens infected with Cryptosporidium baileyi
Metabolites | KEGG ID | Ion mode | AUC | VIP | FDR (q-value) | log2(FC) | Pathways (FDR < 0.05) |
|---|---|---|---|---|---|---|---|
All-trans-retinoic acid | C00777 | Positive | 1.000 | 1.542 | 0.002763 | 0.2638 | Intestinal immune network for IgA production |
PE(16:1(9Z)/24:1(15Z)) | C00350 | Positive | 0.9012 | 1.184 | 0.01051 | 0.8962 | Glycerophospholipid metabolism, Autophagy–other, Autophagy–animal |
Sphinganine | C00836 | Positive | 0.9383 | 5.258 | 0.01546 | 0.2760 | Sphingolipid metabolism |
PC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | C00157 | Positive | 0.8642 | 1.155 | 0.02174 | 0.4605 | Glycerophospholipid metabolism |
Phosphocholine | C00588 | Positive | 0.9012 | 1.660 | 0.02200 | 0.3740 | Glycerophospholipid metabolism |
PC(14:0/22:1(13Z)) | C00157 | Positive | 0.9383 | 19.19 | 0.02364 | 1.364 | Glycerophospholipid metabolism |
SM(d18:0/16:1(9Z)(OH)) | C00550 | Positive | 0.9259 | 5.159 | 0.02786 | 0.3067 | Sphingolipid metabolism |
Choline | C00114 | Positive | 0.8765 | 1.257 | 0.04110 | 0.4412 | Glycerophospholipid metabolism |
Sirolimus | C07909 | Negative | 0.8765 | 2.448 | 0.04846 | 0.1805 | Cellular senescence |