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Table 3 Potential serum biomarkers response to C. baileyi infection in chickens based on receiver operating characteristic curve analysis

From: Serum metabolomics in chickens infected with Cryptosporidium baileyi

Metabolites KEGG ID Ion mode AUC VIP FDR (q-value) log2(FC) Pathways (FDR < 0.05)
All-trans-retinoic acid C00777 Positive 1.000 1.542 0.002763 0.2638 Intestinal immune network for IgA production
PE(16:1(9Z)/24:1(15Z)) C00350 Positive 0.9012 1.184 0.01051 0.8962 Glycerophospholipid metabolism, Autophagy–other, Autophagy–animal
Sphinganine C00836 Positive 0.9383 5.258 0.01546 0.2760 Sphingolipid metabolism
PC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) C00157 Positive 0.8642 1.155 0.02174 0.4605 Glycerophospholipid metabolism
Phosphocholine C00588 Positive 0.9012 1.660 0.02200 0.3740 Glycerophospholipid metabolism
PC(14:0/22:1(13Z)) C00157 Positive 0.9383 19.19 0.02364 1.364 Glycerophospholipid metabolism
SM(d18:0/16:1(9Z)(OH)) C00550 Positive 0.9259 5.159 0.02786 0.3067 Sphingolipid metabolism
Choline C00114 Positive 0.8765 1.257 0.04110 0.4412 Glycerophospholipid metabolism
Sirolimus C07909 Negative 0.8765 2.448 0.04846 0.1805 Cellular senescence
  1. KEGG Kyoto Encyclopedia of Genes and Genomes, AUC area under the curve