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Table 1 Table displaying IC50, TC50 and SI values of extracts with specific activity against Vero and HepG2 cell

From: Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease

No. extract Plant species of origin Country of collection Part of the plant* IC50 (ppm) TC50a (ppm) SIa TC50b (ppm) SIb IC50c (ppm) SIa,c SIb,c
BNZ 0.40 69.60 174.0 51.47 128.7 0.53 131.4 97.6
51 Amaryllis belladonna Chile B 1.65 42.00 25.43 128.2 77.7 37.29 1.1 3.4
81 Crinum amabile Venezuela B 5.42 211.5 38.99 266.9 49.2 25.86 8.2 10.4
93 Crinum amabile Ecuador B 2.21 60.69 27.46 111.3 50.3 20.57 2.9 5.4
56 Crinum erubescens Bolivia B 9.50 234.7 24.69 678.3 71.4 11.10 21.1 61.1
101 Eucharis formosa Ecuador B 9.71 346.7 35.71 778.9 80.2 26.93 12.9 28.9
23 Rhodophiala andicola Chile B 6.20 134.9 21.75 77.37 12.5
24 Rhodophiala andicola Chile AP 6.13 228.4 37.27 188.1 30.7 10.18 22.4 18.5
  1. Extracts that showed specific anti-amastigote activity with SI > 10 with respect to Vero and HepG2 cell toxicity assays are highlighted in bold
  2. B bulbs, AP aerial parts
  3. aTC50 on Vero cells toxicity assay
  4. bTC50 on HepG2 cells toxicity assay
  5. cAnti-amastigote assay