Skip to main content

Table 1 Table displaying IC50, TC50 and SI values of extracts with specific activity against Vero and HepG2 cell

From: Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease

No. extract

Plant species of origin

Country of collection

Part of the plant*

IC50 (ppm)

TC50a (ppm)

SIa

TC50b (ppm)

SIb

IC50c (ppm)

SIa,c

SIb,c

BNZ

–

–

–

0.40

69.60

174.0

51.47

128.7

0.53

131.4

97.6

51

Amaryllis belladonna

Chile

B

1.65

42.00

25.43

128.2

77.7

37.29

1.1

3.4

81

Crinum amabile

Venezuela

B

5.42

211.5

38.99

266.9

49.2

25.86

8.2

10.4

93

Crinum amabile

Ecuador

B

2.21

60.69

27.46

111.3

50.3

20.57

2.9

5.4

56

Crinum erubescens

Bolivia

B

9.50

234.7

24.69

678.3

71.4

11.10

21.1

61.1

101

Eucharis formosa

Ecuador

B

9.71

346.7

35.71

778.9

80.2

26.93

12.9

28.9

23

Rhodophiala andicola

Chile

B

6.20

134.9

21.75

77.37

12.5

–

–

–

24

Rhodophiala andicola

Chile

AP

6.13

228.4

37.27

188.1

30.7

10.18

22.4

18.5

  1. Extracts that showed specific anti-amastigote activity with SI > 10 with respect to Vero and HepG2 cell toxicity assays are highlighted in bold
  2. B bulbs, AP aerial parts
  3. aTC50 on Vero cells toxicity assay
  4. bTC50 on HepG2 cells toxicity assay
  5. cAnti-amastigote assay