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Table 6 Pyrethroid resistance implications of voltage-sensitive sodium channel (Vssc) mutations in Aedes aegypti from the Kingdom of Saudi Arabia (Al Safa and Al Rawabi districts of Jeddah)

From: Voltage-sensitive sodium channel (Vssc) mutations associated with pyrethroid insecticide resistance in Aedes aegypti (L.) from two districts of Jeddah, Kingdom of Saudi Arabia: baseline information for a Wolbachia release program

Genotype V1016G F1534C S989P Resistance implication References
A GG
GG
TT
FF
CC
PP
Confers resistance to Type I and type II pyrethroids (HIGH LEVEL) Plernsub et al. [32]
B TT
VV
GG
CC
TT
SS
Confers resistance to Type I pyrethroids (LOW LEVEL) Plernsub et al. [32]
C TG
VG
TG
FC
TC
SP
Heterozygote (C)—confers low level of resistance to Type I and Type II pyrethroids (INTERMEDIATE LEVEL) Plernsub et al. [32]
D TG
VG
TT
FF
TC
SP
Type II pyrethroids (practically SUSCEPTIBLE) Plernsub et al. [32]
E TT
VV
TG
FC
TT
SS
May confer low level of resistance to Type I pyrethroids (not much higher than wildtype) Plernsub et al. [32]
I GG
GG
TG
FC
CC
PP
Resistance level conferred by this genotype has not been fully ascertained—possibly susceptible to Type II pyrethroids Al Nazawi et al. [5]
J TG
VG
GG
CC
TC
SP
Resistance level conferred by this genotype has not been fully ascertained—possibly susceptible to Type II pyrethroids Al Nazawi et al. [5]
K GG
GG
GG
CC
CC
PP
Triple mutant homozygote—Extremely high resistance when created artificially in Xenopus oocytes—Resistance in nature not known. May have high fitness costs—possibly susceptible to Type II pyrethroids Hirata et al. [38], Al Nazawi et al. [5]
L TG
VG
TG
FC
TG
SP
Putative triple heterozygote (L)—resistance level conferred, if any, is not known