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Table 5 Cut-off values, sensitivity and specificity of the index InBios ELISA tests using the primary (fecal test) and secondary (CRS) reference standards

From: Diagnostic accuracy of a novel enzyme-linked immunoassay for the detection of IgG and IgG4 against Strongyloides stercoralis based on the recombinant antigens NIE/SsIR

Reference standard Indeterminate cases Test Cut-off value Sensitivity (95% CI) Pa Specificity (95% CI) Pa
Primary—fecal test n/a IgG 0.714 0.93 (0.88–0.97)  < 0.0001 0.91 (0.88–0.95) 0.0325
Primary—fecal test n/a IgG4 0.609 0.81 (0.74–0.87) 0.94 (0.91–0.97)
Secondary—CRS Excluded IgG 0.675 0.78 (0.72–0.83) 0.0011 0.98 (0.96–1.00) 0.6547
Secondary—CRS Excluded IgG4 0.32 0.70 (0.64–0.76) 0.97 (0.95–1.00)
Secondary—CRS Included as negative cases IgG 0.885 0.76 (0.71–0.82) 0.5316 0.98 (0.96–1.00) 0.0004
Secondary—CRS Included as negative cases IgG4 0.064 0.75 (0.69–0.81) 0.91 (0.88–0.95)
Secondary—CRS Included as positive cases IgG 0.675 0.54 (0.48–0.59) 0.0082 0.98 (0.96–1.00) 0.6547
Secondary—CRS Included as positive cases IgG4 0.32 0.49 (0.43–0.54) 0.97 (0.95–1.00)
  1. CI, Confidence interval; CRS, composite reference standard, n/a, not available
  2. aP-values comparing sensitivities and specificities were determined by McNemar’s test