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Table 1 Proteomic content (directly measured or inferred) of the secretomes of different parasite species

From: The parasite Schistocephalus solidus secretes proteins with putative host manipulation functions

Parasitic species Host species Manipulation factor Host system targeted Reference
78 helminth species: 64 nematodes, 7 trematodes, 7 cestodes (1) Humans, animals, and plants Peptidases (61% of species) Immune system Helminth secretome database (HSD)
Garg and Ranganathan [15]
Blood fluke
Schistosoma mansoni (1)
Humans Proteins involved in calcium binding and regulation Neural system
(affects cell signalization)
Knudsen et al. [12]
Blood fluke
Schistosoma mansoni (1)
Humans Paramyosin and SPO-1 Immune system (evasion) Knudsen et al. [12]
Blood fluke
Schistosoma mansoni (1)
Humans Proteases Immune system (degradation of skin barriers) Knudsen et al. [12]
Liver fluke
Fasciola hepatica (1)
Molluscs (e.g. Galba truncatula) Proteases and antioxidant enzymes:
Cu/Zn-superoxide dismutase + thioredoxin
Immune system (evasion) Cwiklinski and Dalton [16]
Gourbal et al. [13]
Cestode
Spirometra erinacei (1)
Snakes
Rhabdophis tigrinus
Specific proteins with no identified homologsa Unknown Kim et al. [17]
Cestode
Hymenolepis diminuta (1)
Rats
Rattus rattus
Antigens Immune system
(evasion and modulation)
Bień et al. [18]
Baculovirus
Bombyx mori NPV (2)
Silkworm
Bombyx mori
Protein tyrosine phosphatasea Neural system (enhanced locomotory activity) Kamita et al. [19]
Hairworm
Spinochordodes tellinii + Paragordius tricuspidatus (2)
Grass-hopper Meconema thalassinum + cricket
Nemobius sylvestris
Wnta Neural system (modifications of monoamine levels) Biron et al. [20]
[21]
Protozoan
Toxoplasma gondii (2)
Rat
Rattus rattus
Tyrosine hydroxylasea Neural system (increases dopamine levels) Prandovszky et al. [22]
Fungus
Ophiocordyceps unilateralis (2)
Ant Camponotus pennsylvanicus and
Formica dolosa
Guanobutyric acid (GBA) and sphingosine Neural system (action not determined) De Bekker et al. [23]
Wasp
Cotesia congregata (2)
Caterpillar
Manduca sexta
Cytokinea Immune system (activation that results in feeding reduction) Adamo et al. [24]
Wasp
Ampulex compressa (2)
Cockroach Periplaneta americana Dopamine Neural system (represses the activity of neurons) Libersat et al. [25]
Aphid
Hormaphis cornu (2)
Witch hazel
Hamamelis virginiana
BICYCLE protein Development (induces galls—novel plant ‘organs’) Korgaonkar et al. [26]
  1. (1) Species of human importance. (2) Species studied in the context of behavioural manipulation. aProteins inferred from experimental or bioinformatics evidence, i.e. proteins not directly measured in the secretome