Fig. 5From: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecanCovalent simulations reporting the three-dimensional arrangement of the catalytic pentad in the four systems and its intra-pentad and pentad-DNA hydrogen bonds. WT: top-left panel; F187Y: top-right panel; G191A: bottom-left panel; and W242R: bottom-right panel. The residue–residue interactions are highlighted by a red lineBack to article page