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Fig. 6 | Parasites & Vectors

Fig. 6

From: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Fig. 6

Non-covalent simulations, reporting the three-dimensional arrangement of the catalytic pentad in the four systems and its intra-pentad and pentad-DNA hydrogen bonds. WT: top-left panel; F187Y: top-right panel; G191A: bottom-left panel; and W242R: bottom-right panel. The residue–residue interactions are highlighted by a red line, while those occurring with the DNA are shown with a light blue line

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Parasites & Vectors

ISSN: 1756-3305

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