Table 1 Overview of the common mutated genes in the three TPT-resistant mutants
Mutant | Gene ID | Mutation position | Allele frequency | Ref/Mut AA | Gene function |
|---|---|---|---|---|---|
TPT700.1 TPT700.2 TPT700.3 | LinJ.01.0420 | 1073 1073 1073 | Het Het Het | A/E A/E A/E | Hypothetical protein conserved |
TPT700.1 TPT700.2 TPT700.3 | LinJ.09.0680 | 1388 1388 1388 | Hom Hom Hom | na na na | Hypothetical protein conserved |
TPT700.1 TPT700.2 TPT700.3 | LinJ.09.0950 | 17 17 17 | Hom Hom Hom | na na na | Polyubiquitin |
TPT700.1 TPT700.2 TPT700.3 | LinJ.12.0662 | 425 425 425 | Het Het Het | S/T S/T S/T | Surface antigen protein putative |
TPT700.1 TPT700.2 TPT700.3 | LinJ.19.1680 | 3792 3665 2940 | Het Het Hom | na V/A E/D | Hypothetical protein |
TPT700.1 TPT700.2 TPT700.3 | LinJ.19.1690 | 3956 3389 3956 | Het Het Het | S/N G/A S/N | Hypothetical protein |
TPT700.1 TPT700.2 TPT700.3 | LinJ.24.1120 | 771 776 771 | Het Het Het | S/R S/F S/R | Pre-mRNA splicing factor putative |
TPT700.1 TPT700.2 TPT700.3 | LinJ.27.0870 | 2572 2572 2572 | Het Het Het | R/G R/G R/G | Hypothetical protein conserved |
TPT700.1 TPT700.2 TPT700.3 | LinJ.28.2320 | 856 856 856 | Hom Hom Hom | N/Y N/Y N/Y | Hypothetical protein conserved |
TPT700.1 TPT700.2 TPT700.3 | LinJ.28.2390 | 1321 1321 1321 | Hom Hom Hom | na na na | Cyclin-dependent kinase-binding protein putative |
TPT700.1 TPT700.2 TPT700.3 | LinJ.28.2450 | 3758 3758 3758 | Hom Hom Hom | na na na | DNA topoisomerase ii |
TPT700.1 TPT700.2 TPT700.3 | LinJ.29.1450 | 242 242 242 | Hom Het Hom | A/V A/V A/V | Amastin-like protein |
TPT700.1 TPT700.2 TPT700.3 | LinJ.29.2240 | 1267 1267 1267 | Hom Hom Hom | L/F L/F L/F | Hypothetical protein conserved |
TPT700.1 TPT700.2 TPT700.3 | LinJ.31.1470 | 1088 1088 1109 | Hom Hom Het | na na na | Hypothetical protein unknown function |
TPT700.1 TPT700.2 TPT700.3 | LinJ.34.0710 | 2129 76 2843 | Het Het Het | G/D A/P D/G | Flagellar attachment zone protein putative |
TPT700.1 TPT700.2 TPT700.3 | LinJ.34.3220 | 560 572 724 | Hom Het Hom | F/Y G/A W/R | DNA topoisomerase IB large subunit |
TPT700.1 TPT700.2 TPT700.3 | LinJ.35.0490 | 16,451 1992 16,285 | Hom Het Hom | R/H na V/I | Proteophosphoglycan ppg4 |
TPT700.1 TPT700.2 TPT700.3 | LinJ.35.0510 | 7549 5278 2437 | Het Het Het | A/T V/L G/S | Proteophosphoglycan ppg4 |
TPT700.1 TPT700.2 TPT700.3 | LinJ.35.0550 | 1699 2471 2471 | Het Het Hom | A/T na na | Proteophosphoglycan ppg1 |