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Table 1 Cytotoxicity and anti-MAYV activity of punicalagin and ethanol extract of pomegranate

From: Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus

Substance CC50a IC50b IS50c RPd
Pomegranate ethanol extract 590.8 ± 17.7 12.3 ± 0.4 48 6
Punicalagin 425 ± 12.8 29.9 ± 0.9 14 1.75
Ribavirin 523.1 ± 10.5 62.5 ± 4.4 8
  1. a50% cytotoxic concentration
  2. b50% inhibitory concentration of viral replication
  3. cSelectivity index = CC50/IC50
  4. dRelative potency = IS50(substance)/IS50(ribavirin)