Fig. 1From: Schistosoma japonicum peptide SJMHE1 inhibits acute and chronic colitis induced by dextran sulfate sodium in miceTreatment with the Schistosoma japonicum small molecule peptide, SJMHE1, alleviated colon inflammation in mice with DDS-induced acute colitis. a Experimental scheme. C57BL/6 mice were provided with drinking water containing 2.5% DSS for 10 days. They were injected with SJMHE1 or PBS emulsified in IFA on days 0 and 7. The mice were killed on day 10. bDisease activity index (b) and rate of body weight change (c) in each group. d Macroscopic appearance of colon. e Colon length in each group. f Histological analysis of the colon from mice with H&E staining (magnification 20×). Images represent the results of three independent experiments (total n = 18 mice, 6 mice per group). g Histological scores were assessed from each mouse. Data are presented as mean ± standard error of the mean (SEM; n = 18) of three independent experiments. Asterisks indicate significant difference at: *P < 0.05, **P < 0.01, ***P < 0.001Back to article page