Table 1 Antigens used to perform antibody capture assays for the diagnosis of lymphatic filariasis
From: Recombinant antigens used as diagnostic tools for lymphatic filariasis
Antigen | Sensitivity (%) | Specificity (%) | Cross-reactivity | Test used | References | |
|---|---|---|---|---|---|---|
Bm | Wb | |||||
BmSXP | 0 | 78 | Not shown | Yes (O. volvulus, M. perstans and Loa loa) | ELISA | [31] |
| Â | 84 | 95 | 99 | Yes (O. volvulus, and Loa loa) | ELISA | [21] |
|  | – | 97.6 | 99.6 | Yes (other infections) | WB Rapid | [53] |
|  | – | – | – | Not tested | BLF Rapid | [28] |
|  | – | 94 | 100 | Not tested | BLF Rapid | [54] |
Bm14 | 90 | Not shown | Yes (O. volvulus) | ELISA | [19] | |
|  | – | > 90 | Not shown | No (non-filarial helminthiasis) | ELISA | [59] |
| Â | 91 | 96 | Not shown | Yes (O. volvulus and Loa loa) | CELISA | [15] |
| Â | 91 | 98 | Not shown | Yes (Ascaris and Strongyloides) | CELISA | [18] |
WbSXP-1 | – | 100 | Not shown | Yes (Loa loa) | ELISA | [30] |
| Â | 90.8 | 91.4 | 100 | Yes (Loa loa) | Rapid test | [65] |
| Â | 39 | 91 | Not shown | Yes (O. volvulus, and Loa loa) | ELISA | [15] |
Wb14 | Not shown | Not shown | Not tested | ELISA | [32] | |
|  | – | 90 | 96.6 | Yes (Strongyloides) | ELISA | [62] |
(WbT) | – | 90 | 96.6 | Yes (Strongyloides) | ELISA | [62] |
WbL1 | – | 93 | 98 | Yes (not specified) | ELISA | [33] |
Bm33 | Not shown | Not shown | Yes (O. volvulus) | ELISA | [37] | |
| Â | Not shown | Not shown | Not tested | ELISA | [40] | |
BmALT-1 | Not shown | Not shown | Not tested | ELISA | [41] | |
BmALT-2 | Not shown | Not shown | Not tested | ELISA | [43] | |
BmR1 | 96 | – | 95 | No (other infections) | ELISA | [14] |
|  | 97 | – | 99 | Yes (other infections) | BmR1 Dipstick | [29] |
| Â | 100 | 45 | Not shown | No (O. volvulus, and Loa loa) | ELISA | [15] |
| Â | 100 | 56.7 | Not shown | Yes (O. volvulus) | BmR1 Dipstick | [15] |
| Â | 98 | 14 | 100 | No (O. volvulus, and Loa loa) | ELISA | [21] |
BmSXP + BmR1 | 98 | 84 | 99 | No (other infections) | ELISA | [21] |
| Â | 97.2 | 96 | 99.6 | Yes (other infections) | PanLF Rapid | [53] |
BmVAH | Not shown | Not shown | Not tested | ELISA | [50] | |
WbVAH | Not shown | Not shown | Not tested | ELISA | [51] | |
Wb123 | Not shown | 100 | 100 | Yes (O. volvulus, Loa loa) | LIPS | [52] |
|  | – | 93 | 97 | Yes (O. volvulus) | ELISA | [17] |
|  | – | 92 | 96 | Yes (O. volvulus) | Rapid test | [17] |
|  | – | 92.6 | 95.7 | Yes (O. volvulus) | Rapid test | [20] |
| Â | Not shown | Not shown | Not tested | Luminex | [80] | |
Bm Shp-1 | Not shown | Not shown | Not tested | ELISA | [83] | |