Fig. 4
The RH-Δompdc mutant could be eliminated in mice and induced intense host immune responses. The 6- to 8-week-old BALB/c mice were infected with 106 RH-WT and RH-Δompdc tachyzoites (i.p.), and the parasite burden in the peritoneal fluids and the levels of IL-12 and IFN-γ in the serum were detected at 0, 12, 24 h, and 5 d post infection. a The parasite burden in the peritoneal fluids of mice (n = 4) infected with RH-WT and RH-Δompdc tachyzoites was detected at the indicated time post infection. The B1 gene was detected by qPCR to demonstrate the number of T. gondii tachyzoites in each sample. b IL-12 level in mice serum (n = 5). c IFN-γ level in mice serum (n = 4). Results are representative of three independent experiments. Data were analyzed by one-way ANOVA with Tukey’s test. Asterisks indicate significant difference at ****P < 0.0001