Assessing antibody decline after chemotherapy of early chronic Chagas disease patients

Parasites & Vectors

Table 2 Univariate associations with IgG1 and IgG serology

ELISA antigen	Category	Categories	N	IgG Pre-treatment		IgG Post-treatment		IgG1 Pre-treatment		IgG1 Post-treatment
				Mean absorbance value	t-test P-value	Mean absorbance value	t-test P-value	Mean absorbance value	t-test P-value	Mean absorbance value	t-test P-value
Lysate	Ethnic group	Creole	30	1.120	0.355	0.650	0.364	0.599	0.045*	0.244	0.529
	Ethnic group	Qom	28	0.950	0.355	0.541	0.364	0.980	0.045*	0.307	0.529
	Completed treatment	Yes	58	1.038	0.540	0.597	0.209	0.783	0.079	0.274	0.013*
	Completed treatment	No	13	1.159	0.540	0.778	0.209	1.180	0.079	0.589	0.013*
	Pre-treatment kDNA-PCR result	Positive	24	1.270	0.092	0.676	0.019*	0.910	0.156	0.121	0.281
	Pre-treatment kDNA-PCR result	Negative	10	0.854	0.092	0.315	0.019*	0.557	0.156	0.267	0.281
TSSApep-II/V/VI	Ethnic group	Creole	26	0.700	0.030*	0.111	0.584	0.593	0.256	0.033	0.682
	Ethnic group	Qom	27	0.321	0.030*	0.091	0.584	0.327	0.256	0.046	0.682
	Completed treatment	Yes	53	0.507	0.049*	0.101	< 0.0001***	0.478	0.660	0.038	0.261
	Completed treatment	No	13	0.964	0.049*	0.478	< 0.0001***	0.336	0.660	0.081	0.261
	Pre-treatment kDNA-PCR result	Positive	21	0.738	0.640	0.105	0.996	0.591	0.194	0.0233	0.429
	Pre-treatment kDNA-PCR result	Negative	9	0.592	0.640	0.105	0.996	0.172	0.194	0.012	0.429

ISSN: 1756-3305