Fig. 6

Antischistosomal effect of PZQ combined with DW-3-15 in vivo. The untreated control group was treated with 0.5% carboxymethyl cellulose sodium. Compounds were given to mice at 14 days post-infection (against 14-day-old juvenile), 21 days post-infection (with a reinfection at 14 days post-infection, against multiple developmental stages), and 28 days post-infection (against 28-day-old adult worms). Data represent mean ± SEM from multiple-group experiments. Statistical analysis was performed among control, monotherapy, and combination groups using one-way ANOVA followed by Dunnett’s test. Significant differences are indicated by **P < 0.01, ***P < 0.001, and ****P < 0.0001