Table 3 Genotypic and allelic frequencies of Kdr L1014F and Ace-1R G119S gene mutations between infected and uninfected Anopheles gambiae and Anopheles coluzzii
Species | Study arm | SNP/status | n | Genotypic frequencies [x (%)] | Allelic frequencies [y (%)] | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|
RR | RS | SS | R | S | |||||
Kdr L1014F | |||||||||
An. coluzzii | Control | Infected | 213 | 102 (47.89) | 96 (45.07) | 15 (7.04) | 300 (70.42) | 126 (29.58) | 1 |
Uninfected | 208 | 102 (49.04) | 86 (41.35) | 20 (9.62) | 290 (69.71) | 126 (30.29) | 1.03 (0.76–1.38) | ||
SET | Infected | 92 | 40 (43.48) | 46 (50.00) | 6 (6.52) | 126 (68.48) | 58 (31.52) | 1 | |
Uninfected | 118 | 60 (50.85) | 43 (36.44) | 15 (12.71) | 163 (69.07) | 73 (30.93) | 0.97 (0.62–1.5) | ||
An. gambiae | Control | Infected | 187 | 183 (97.86) | 3 (1.60) | 1 (0.53) | 369 (98.66) | 5 (1.35) | 1 |
Uninfected | 208 | 207 (99.52) | 1 (0.47) | 0 (0) | 415 (99.76) | 1 (0.24) | 0.17 (0.003–1.6) | ||
SET | Infected | 119 | 117 (98.32) | 2 (1.68) | 0 (0) | 236 (99.16) | 2 (0.84) | 1 | |
Uninfected | 110 | 109 (99.1) | 1 (0.9) | 0 (0) | 219 (99.55) | 1 (0.45) | 0.53 (0.009–10.4) | ||
Ace-1RG119S | |||||||||
An. coluzzii | Control | Infected | 213 | 4 (1.88) | 23 (10.80) | 186 (87.32) | 31 (7.28) | 395 (92.72) | 1 |
Uninfected | 207 | 8 (3.86) | 29 (14.01) | 170 (82.13) | 45 (10.87) | 369 (89.13) | 0.64 (0.38–1.06) | ||
SET | Infected | 92 | 0 (0) | 9 (9.78) | 83 (90.22) | 9 (4.89) | 175 (95.11) | 1 | |
Uninfected | 118 | 2 (1.69) | 15 (12.71) | 15 (85.60) | 19 (8.05) | 217 (91.95) | 0.58 (0.22–1.40) | ||
An. gambiae | Control | Infected | 186 | 15 (8.06) | 42 (22.58) | 129 (69.35) | 72 (19.32) | 300 (80.64) | 1 |
Uninfected | 208 | 21 (10.10) | 52 (25.00) | 135 (64.90) | 94 (22.60) | 322 (77.40) | 0.82 (0.57–1.17) | ||
SET | Infected | 119 | 7 (5.88) | 25 (21.01) | 87 (73.11) | 39 (16.39) | 199 (83.61) | 1 | |
Uninfected | 109 | 9 (8.26) | 19 (17.43) | 81 (74.31) | 37 (16.97) | 181 (83.03) | 0.95 (0.56–1.62) | ||