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Fig. 1 | Parasites & Vectors

Fig. 1

From: Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol

Fig. 1

Boxplot of results of the in vitro resistance tests of Leishmania infantum isolates and L. infantum reference strain MHOM/BR/74/PP75 to the drugs tested. a, b IC50 values of the promastigote (a) and amastigote (b) forms of the isolates and reference strain against miltefosine. c, d IC50 values of promastigote (c) and amastigote (d) forms of the isolates and reference strain against amphotericin B. e, f IC50 values of promastigote (e) and amastigote (f) forms of the isolates and reference strain against meglumine antimoniate. Asterisks indicate statistical significance at *P < 0.05 and **P < 0.01. Abbreviations: IC50, Half maximal inhibitory concentration; T0, prior to commencement of treatment with miltefosine; T1, T2, after 1 and 2 courses of miltefosine treatment, respectively

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