Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance

Parasites & Vectors

Table 1 Preventive efficacy of orally administered moxidectin, ivermectin, and milbemycin oxime against ML-susceptible Dirofilaria immitis at various dosages and treatment times post-inoculation

Macrocyclic lactone (FDA-approved dose)	Dosage (µg/kg)	Treatment time post-inoculation (months)^a	Preventive efficacy (%)	References
Moxidectin	0.5	2	100	[15]
(3 µg/kg)	0.625	2	100	[15]
	1.0	3	47.8	[15]
	1.25	1	100	[15]
	1.25	2	100	[15]
	3.0	1	100	[15]
	3.0	3	64.2	[15]
Ivermectin	1	1	53.2	[42]
(6 µg/kg)	2	1	83.3; 97.2	[41, 42]
	2	1.5	63.8	[42]
	3.3	1	98.1	[42]
	6	1	100	[41]
	6	1.5	100	[41]
Milbemycin oxime	500	1	100	[40]
(500 µg/kg)	500	1.5	100	[40]
	500	2	93.9	[40]

^aDogs were inoculated with 30–50 third-stage larvae utilizing a macrocyclic lactone-susceptible strain

ISSN: 1756-3305