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Table 1 Preventive efficacy of orally administered moxidectin, ivermectin, and milbemycin oxime against ML-susceptible Dirofilaria immitis at various dosages and treatment times post-inoculation

From: Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance

Macrocyclic lactone (FDA-approved dose) Dosage (µg/kg) Treatment time post-inoculation (months)a Preventive efficacy (%) References
Moxidectin 0.5 2 100 [15]
(3 µg/kg) 0.625 2 100 [15]
  1.0 3 47.8 [15]
  1.25 1 100 [15]
  1.25 2 100 [15]
  3.0 1 100 [15]
  3.0 3 64.2 [15]
Ivermectin 1 1 53.2 [42]
(6 µg/kg) 2 1 83.3; 97.2 [41, 42]
  2 1.5 63.8 [42]
  3.3 1 98.1 [42]
  6 1 100 [41]
  6 1.5 100 [41]
Milbemycin oxime 500 1 100 [40]
(500 µg/kg) 500 1.5 100 [40]
  500 2 93.9 [40]
  1. aDogs were inoculated with 30–50 third-stage larvae utilizing a macrocyclic lactone-susceptible strain