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Table 3 Preventive efficacy of various orally administered macrocyclic lactones against the macrocyclic lactone-resistant heartworm strain ZoeLA

From: Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance

Study Treatment Dosage (µg/kg) Day of inoculationa Days of treatment Preventive efficacy (%) References
1 Placebo 0 −30 0, 30, 60, 90, 120, 150 [50]
Simparica Trio (moxidectin) Min. 24 −30 0, 30, 60, 90, 120, 150 97.2 [50]
Heartgard Plus (ivermectin) Min. 6 −30 0, 30, 60, 90, 120, 150 8.5 [50]
Interceptor Plus (milbemycin oxime) Min. 500 −30 0, 30, 60, 90, 120, 150 35.9 [50]
2 Placebo 0 −30 0, 30, 60, 90, 120, 150 [49]
Moxidectin 24 −30 0, 30, 60, 90 96.8 [49]
Moxidectin 24 −30 0, 30, 60, 90, 120, 150 96.1 [49]
Heartgard Plus (ivermectin) Min. 6 −30 0, 30, 60, 90, 120, 150 18.7 [49]
Interceptor Plus (milbemycin oxime) Min. 500 −30 0, 30, 60, 90, 120, 150 21.2 [49]
  1. aEach dog inoculated with 50 third-stage larvae (L3) of the ZoeLA, macrocyclic lactone-resistant strain