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Table 4 Preventive efficacy of various macrocyclic lactones against the macrocyclic lactone-resistant heartworm strain JYD-34

From: Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance

Study Treatment Route of administration Dosage (µg/kg) Day of inoculationa Days of treatment Preventive efficacy (%) References
1 Placebo SC 0 −30 0 [54]
ProHeart 12 (moxidectin) SC 500 −30 0 100 [54]
Heartgard Plus (ivermectin) Oral Min. 6 −30 0, 30, 60, 90, 120, 150 10.5 [54]
Interceptor Plus (milbemycin oxime) Oral Min. 500 −30 0, 30, 60, 90, 120, 150 14.6 [54]
2 Placebo SC 0 165 0 [54]
ProHeart 12 (moxidectin) SC 500 165 0 98.3 [54]
Heartgard Plus (ivermectin) Oral Min. 6 165 0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 37.7 [54]
Interceptor Plus (milbemycin oxime) Oral Min. 500 165 0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 34.9 [54]
3 Placebo Oral 0 −30 0, 30, 60, 90, 120, 150 [49]
Moxidectin Oral 24 −30 0, 30, 60, 90 95.9 [49]
Moxidectin Oral 24 −30 0, 30, 60, 90, 120, 150 99.3 [49]
Heartgard Plus (ivermectin) Oral Min. 6 −30 0, 30, 60, 90, 120, 150 63.9 [49]
Interceptor Plus (milbemycin oxime) Oral Min. 500 −30 0, 30, 60, 90, 120, 150 54.6 [49]
  1. aEach dog inoculated with 50 third-stage larvae (L3) of the JYD-34, macrocyclic lactone-resistant strain