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Table 1 In vitro activity of hits against S. ratti L3 and adults

From: Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis

Drug Effect on L3 (% dead after 72 h), [SD (%)] at 100 µM Effect on adult worms (% dead after 72 h), [SD (%)] at 10 µM Drug indicationd
Aconitine 88.1 (7.5) 17.4 (5.1) Anesthetic (gastric), antipyretic, and cardiotoxin
Acriflavinium HCl 79.4 (7.7) 97.7 (2.3) Anti-infective, intercalating agent
Amantadine HCl 75.5 (8.2) 24.1 (4.0) Antiviral, antiparkinsonian; treatment of drug-induced extrapyramidal reactions
Aminohippuric acid 84.8 (6.3) 32.7 (10.2) Renal function diagnosis
Benzethonium chloride 100.0 (0) 100.0 (0) Anti-infective (topical)
Bitoscanate 100.0 (0) 16.5 (6.4) Anthelmintic
Brinzolamide 82.7 (4.0) 20.1 (11.4) Antiglaucoma
Captamine 91.0 (4.6) 35.1 (9.9) Depigmenting agent
Cetylpyridinium chloride 100.0 (0) 100.0 (0) Anti-infective (topical)
Ceftriaxone sodium trihydrate 100.0 (0) 20.6 (11.9) Antibacterial
Cetrimonium bromide 100.0 (0) 77.3 (11.4) Anti-infective
Chlormidazole 93.3 (5.1) 88.6 (11.4) Antifungal
Chloroxylenol 88.3 (2.2) 64.6 (35.4) Antibacterial, topical, and urinary antiseptic
Chlorpyrifos 100.0 (0) 73.1 (18.8) Insecticide
Cinnarizine 94.7 (1.0) 59.6 (40.06) H1 antihistamine
Coumaphos 100.0 (0) 100.0 (0) Insecticide, cholinesterase inhibitor
Cyproheptadine HCl 100.0 (0) 31.3 (3.7) H1-antihistamine, antipruritic
Dactinomycin 71.4 (6.4) 41.7 (10.4) Antineoplastic, intercalating agent
Debrisoquin sulfate 91.3 (1.5) 8.85 (1.3) Anti-hypertensive
Demeclocycline HCl 81.5 (4.0) – Antibacterial
Dyclonine HCl 100.0 (0) 29.6 (9.5) Anesthetic (topical)
Dibenzothiophene 90.8 (2.8) 13.2 (6.9) Keratolytic
Dimpylate 100.0 (0) 85.6 (15.0) Insecticide, cholinesterase inhibitor
Ebselen 96.6 (1.9) 52.5 (13.4) Antioxidant, lipoxygenase inhibitor, inhibits oxidation of LDL
Edoxudine 89.8 (3.7) 27.2 (7.1) Antiviral
Enilconazole sulfate 71.0 (7.9) 21.9 (3.1) Antifungal
Enoxacin 85.4 (2.9) 44.6 (9.6) Antibacterial
Ethisterone 100.0 (0) 52.4 (24.6) Progestogen
Fenthion 100.0 (0) 87.0 (11.3) Insecticide, ectoparasiticide
Floxuridine 88.9 (2.1) 62.6 (37.5) Antineoplastic, antimetabolite
Gallamine triethiodide 88.5 (2.9) 43.1 (11.3) Muscle relaxant (skeletal)
Gentian violet 100.0 (0) 100.0 (0) Antibacterial, anthelmintic
Gramicidinb 72.7 (2.0) 32.9 (10.1) Antibacterial
Halcinonide 96.1 (0.9) 38.7 (4.3) Glucocorticoid, anti-inflammatory
Hexylresorcinol 83.6 (3.2) 28.8 (8.7) Anthelmintic, topical antiseptic
Hycanthone 78.0 (15.0) 29.3 (13.5) Anthelmintic, hepatotoxic
Hydrocortisone butyrate 77. 8 (4.0) 54.3 (20.4) Glucocorticoid, anti-inflammatory
Imiquimod HCl 80.6 (9.2) 64.4 (24.3) Immunomodulator
Indapamide 70.1 (6.0) 36.6 (16.5) Diuretic, antihypertensive
Inositol 75.9 (4.1) 28.9 (8.9) Growth factor
Iodoquinol 70.8 (5.1) 17.9 (2.2) Anti-amoebic
Isoxicam 89.5 (2.8) 19.3 (3.6) Anti-inflammatory
Ivermectin 100.0 (0) 8.9 (1.25) Antiparasitic
Kanamycin A sulfate 71.0 (3.1) 50.9 (7.0) Antibacterial
Labetalol HCl 79.9 (8.3) 41.0 (13.2) Adrenergic blocker
Lasalocid sodium 88.7 (1.6) 10.9 (12.0) Antibacterial
Levamisole HCl 93.1 (4.5) 88.6 (11.4) Immunomodulatory, anthelmintic
Malathion 100.0 (0) – Pediculicide, insecticide, cholinesterase inhibitor
Megestrol acetate 73.3 (5.54) 51.4 (2.92) Progestogen, antineoplastic
Methylbenzethonium chloride 91.5 (1.4) 100.0 (0)c Anti-infective
Methylthiouracil 100.0 (0) 34.3 (14.2) Antithyroid agent
Mianserin HCl 100.0 (0) 19.6 (6.9) 5HT antagonist
Mitoxantrone HCl 92.6 (9.8) 39.8 (3.1) Antineoplastic
Morantel citrate 100.0 (0) 100.0 (0) Anthelmintic
Nadolol 84.6 (5.8) 52.5 (17.5) Beta-adrenergic blocker
Niclosamide 76.3 (15.2) – Anthelmintic, teniacide
Norethynodrel 100.0 (0) 36.8 (5.3) Progestogen, in combination with estrogen as oral contraceptive
Oxethazaine 82.9 (6.34) – Anesthetic (local)
Phenothiazine 93.3 (0.8) 37.1 (2.2) Anthelmintic
Prasterone acetate 88.6 (7.7) 77.1 (22.8) Adrenocortical hormone, antidepressant
Prednicarbate 100.0 (0) 29.9 (13.2) Anti-inflammatory, glucocorticoid
Prilocaine HCl 88.5 (2.2) 25.1 (5.1) Anesthetic (local)
Proadifen HCl 74.9 (4.8) 21.3 (1.2) Cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)
Propiolactone 92.8 (2.0) 49.5 (4.81) Anti-infective
Pyrantel pamoate 100.0 (0) 53.0 (32.9) Anthelmintic
52.9 (3.9)a
Selamectin 79.9 (8.1) – Anthelmintic, antiparasitic, anti-mite
Sulfanitran 100.0 (0) 65.7 (24.8)c Antibacterial, coccidiostat
Terpene hydrate 70.5 (16.6) 18.4 (4.5) Expectorant
Tetroquinone 85.4 (4.9) 42.9 (11.4)c Keratolytic
Triflupromazine HCl 90.6 (5.6) – Antipsychotic
Tylopaxol 84.1 (8.3) 43.8 (11.2) Polymeric nonionic detergent
  1. Hits are defined as compounds with 70% activity against S. ratti L3
  2. aConsidering salt factor (29 µM), empty cells reflect missing drug
  3. bGramicidin A (87%), B (7%), C (5%), and D (1%) ex Bacillus brevis
  4. cOnly tested once. SD was calculated between individual wells
  5. dIndication according to library provider (Pharmakon)
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