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Table 2 IC50 values of levamisole against larval and adult S. ratti at 24, 48, and 72 h

From: Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis

Developmental stage Evaluation time point (h) Concentration tested (µM)
100 10 1 0.1 IC50 value
L3 24 79.5 (8.4) 73.3 (4.5) 55.2 (25.2) 14.2 (1) 2.05
48 94 8 (2.5) 92.7 (2.9) 90.3 (3.0) 16.8 (0.7) 0.25
72 98.4 (2.8) 97.1 (2.6) 91.7 (4.4) 28.45 (2.8) 0.12
Adult 24 39.1 (2.3) 33.1 (2.1) 30.8 (1.9) 20.4 (5.6) > 100
48 87.5 (4.5) 84.6 (2.3) 75.0 (3.1) 25.5 (0) 0.35
72 92.7 (2.2) 82.8 (1.4) 76.8 (2.3) 43.9 (3.5) 0.11