A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva

Parasites & Vectors

Table 1 Number of proteins identified in saliva of Ornithodoros erraticus females and males by LC–MS/MS and SWATH-MS as classified in 24 different functional groups and families

Classification	LC–MS/MS			SWATH (female + male)
Classification	Adult pool	Female	Male	SWATH (female + male)
Antimicrobial	2	2	2	2
Antioxidant/detoxification^a	22	12	19^a	16
Cytoskeletal	17	14	11	10
Extracellular matrix	13	11	5	6
Glycine rich	3	3	3	3
Heme/iron binding	11	10	9	10
Immune related	12	10	8	7
Lipocalin^a	25	18	20^a	16
Metabolism, amino acids	1	1	1	1
Metabolism, carbohydrates^a	22	8	20^a	19
Metabolism, energy^a	16	5	14^a	7
Metabolism, lipids	14	10	10	10
Metabolism, nucleic acids^a	18	11	15^a	6
Nuclear regulation	16	13	7	4
Protease	44	31	29	24
Protease inhibitor	32	28	23	26
Proteasome machinery	8	4	4	1
Protein modification	9	5	5	5
Protein synthesis	5	4	1	1
Signal transduction	11	9	4	5
Transcription machinery	2	1	1	–
Transporter/receptors	22	16	14	11
Transposon element	3	2	2	1
Unknown function	59	46	36	33
Total	387	274	263	224

Additional details can be found in Additional file 1: Table S1
^aFunctional groups and families containing a higher number of proteins in male than in female saliva

ISSN: 1756-3305