A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva

Pérez-Sánchez, Ricardo; Carnero-Morán, Angel; Luz Valero, M.; Oleaga, Ana

doi:10.1186/s13071-021-05118-1

Parasites & Vectors

Table 2 Proteins differentially expressed between female and male saliva

From: A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva

Functional category	Accession	Description	Mean signal peak area × 10³ (n = 3)—female	Mean signal peak area × 10³ (n = 3)— male	Fold change (female/male)	P-value^a
Antimicrobial	ACB70385	Hebreain-like protein	95.60	313.28	0.31	1.31E−02
Antioxidant/detoxification	B7PHC3	Carbon–nitrogen hydrolase, putative	2086.45	320.63	6.51	3.10E−02
	PRD32710	Mitochondrial amidoxime reducing component 2	755.23	160.62	4.70	2.83E−03
	B7PQF4	Sulfotransferase, putative	30.34	73.69	0.41	1.86E−02
	B7QGH2	Glutathione S-transferase, putative	161.86	495.61	0.33	6.81E−03
	ABI52820	Superoxide-dismutase	99.49	325.97	0.31	1.88E−02
	AWM72026	Catalase 1	716.85	2,616.34	0.27	2.61E−02
	RZF47230	Hypothetical protein LSTR_LSTR004939	84.68	684.44	0.12	3.09E−06
Cytoskeletal	ABP01547	beta-Actin	631.00	966.00	0.65	4.54E−02
Extracellular matrix	AAS01023	Mucin/peritrophin-like protein precursor	81.49	0.05	1,644.20	4.72E−02
	XP_015907551	Laminin subunit beta-1 isoform X1	123.26	0.24	524.48	4.34E−02
	B7Q2R9	Cell adhesion molecule, putative	14.83	51.41	0.29	2.66E−03
Glycine rich	B7Q6J2	Glycine proline-rich secreted protein, putative	2406.02	748.22	3.22	3.30E−02
Heme/iron binding	AXP34687	Vitellogenin-1	6447.77	4.84	1333.20	3.47E−02
	AJR36491	Hemelipoglyco-carrier protein CP3	3552.23	8.50	418.01	2.25E−03
	ISCW021710-PA	CP3	866.12	25.82	33.54	8.62E−05
	AXP34690	Vitellogenin-B	1595.72	357.35	4.47	3.18E−02
Immune related	B7Q4R4	Double sized immunoglobulin G binding protein A	3993.51	779.57	5.12	1.32E−02
	DAA34752	Ixodegrin	44.01	135.43	0.32	3.96E−02
	AAM54048	Savignygrin	92.22	1021.83	0.09	4.38E−06
Lipocalin	ABI52661	Lipocalin	785.86	196.68	4.00	1.10E−04
	ACB70384	Salivary lipocalin	2161.01	667.58	3.24	3.86E−02
	ACB70386	Salivary lipocalin, partial	94.71	31.31	3.03	2.93E−02
	ADI60053	Savicalin	2749.89	2389.58	1.15	1.60E−04
	ABR23414	Moubatin-like 3	203.26	406.82	0.50	6.81E−03
	ABI52654	Monotonin	1149.91	2585.77	0.44	7.50E−04
	B7QAQ5	Putative uncharacterised protein (fragment)	28.73	99.58	0.29	2.29E−03
	ABR23394	Truncated salivary lipocalin, partial	15.89	84.78	0.19	2.24E−03
	ABR23399	Moubatin 1-like 2	466.29	6239.00	0.07	2.10E−03
	ABR23443	Salivary secreted lipocalin	35.76	1031.18	0.03	2.63E−03
	ABR23457	Moubatin-like 5	12.16	5932.07	0.00	1.12E−03
Metabolism, amino acids	TDG38496	Hypothetical protein AWZ03_015082	486.14	3401.02	0.14	1.70E−04
Metabolism, carbohydrates	B7QBY6	Glyoxalase, putative	41.51	96.62	0.43	1.22E−02
	XP_013777447	Glucose-6-phosphate isomerase	271.80	808.75	0.34	7.15E−03
	DAA34560	Malate dehydrogenase	81.64	330.49	0.25	7.34E−06
	B7PLL4	Fructose-1,6-bisphosphatase, putative	128.30	534.11	0.24	1.21E−03
	B7Q0R0	Phosphoglycerate mutase, putative	238.67	1208.54	0.20	2.08E−03
	AIW65719	Phosphoglucomutase, partial	15.03	89.67	0.17	3.46E−05
	ADD91327	Enolase	474.65	2936.96	0.16	2.40E−04
	ISCW015616-PA	3-Phosphoglycerate kinase, putative	437.28	2707.91	0.16	1.70E−04
	B7Q3K7	Tpi description	240.42	1591.72	0.15	3.25E−05
	ISCW020197-PA	Pyruvate kinase, putative	273.95	3468.12	0.08	1.74E−03
	ASV64058	Fructose-1,6-bisphosphate aldolase	917.27	15,028.55	0.06	1.20E−04
Metabolism, energy	KDR16306	Glycogen debranching enzyme, partial	109.61	280.36	0.39	7.04E−03
Metabolism, energy	ISCW018700-PA	Glyceraldehyde 3-phosphate dehydrogenase, putative	659.81	5964.82	0.11	1.30E−03
Metabolism, lipids	KFM77310	Apolipoprotein B-100, partial	314.75	3.03	103.96	1.56E−02
	ACB70350	Phospholipase A2, partial	264.73	67.48	3.92	1.39E−02
	AGJ90343	Phospholipase A2	3359.95	3070.84	1.09	2.13E−03
	ABI52805	Phospholipase A2, partial	328.61	812.17	0.40	3.45E−02
	ABR23453	Phospholipase A2	7.81	21.19	0.37	1.15E−02
	CAX51408	Hypothetical protein, partial	39.25	113.37	0.35	2.93E−02
	XP_015915960	Phosphatidylinositol transfer protein alpha isoform	2.92	45.86	0.06	4.20E−03
Metabolism, nucleic acids	B7PCV9	Lysosomal acid phosphatase, putative	2148.64	1148.01	1.87	5.67E−03
	ABS30897	5′-Nucleotidase/putative apyrase isoform 2 precursor	270.86	191.26	1.42	4.18E−03
	AGJ90350	Apyrase	232.08	234.82	0.99	3.72E−02
	B7PJJ3	Adenosine deaminase, putative	95.83	391.27	0.24	6.30E−04
Nuclear regulation	AHN53412	Histone H2B	7.83	22.10	0.35	3.12E−02
Nuclear regulation	XP_017008549	Histone H4-like, partial	2.16	33.42	0.06	4.00E−04
Protease	B7PF28	Longipain, putative	63.26	0.13	500.99	2.57E−02
	AMO02552	Carboxypeptidase Q	86.22	1.90	45.40	4.53E−02
	ABO26562	Cathepsin L-like cysteine protease	659.14	131.99	4.99	1.26E−02
	ISCW004835-PA	Coagulation factor precursor, putative	294.51	60.38	4.88	2.15E−02
	XP_013774340	Carboxypeptidase E-like	270.53	117.03	2.31	3.47E−02
	B7PJ51	Serine carboxypeptidase, putative (Fragment)	1492.78	648.27	2.30	1.90E−03
	XP_019696599	Neprilysin-1	97.36	43.48	2.24	2.21E−02
	ABI52714	Metalloprotease, partial	450.02	211.19	2.13	3.26E−02
	B7QLA0	Riddle, putative (fragment)	1308.48	3209.73	0.41	4.00E−03
Protease inhibitor	ABI94058	Serpin-8 precursor	49.66	2.44	20.35	2.89E−03
	XP_015907865	Hemocytin	7161.53	1838.73	3.89	4.29E−02
	B7P6X9	Hemolectin, putative (fragment)	1431.00	1045.88	1.37	3.44E−02
	KFM64508	Hemocytin, partial	631.61	667.75	0.95	4.25E−02
	AAS01022	Putative thyropin precursor	2472.52	4434.56	0.56	1.26E−02
	P83516	Chymotrypsin-elastase inhibitor ixodidin	382.07	759.34	0.50	2.26E−03
	XP_022121224	Hemocytin	70.57	173.91	0.41	4.28E−02
	XP_023217368	Leukocyte elastase inhibitor A-like isoform X2	19.51	52.26	0.37	4.18E−03
	XP_022255312	Hemocytin-like	22.22	62.06	0.36	7.08E−03
	ACB70299	Ixodidin	16.77	89.06	0.19	1.88E−03
	AAS01021	Cystatin precursor	167.09	1216.49	0.14	1.15E−03
	XP_020288964	Chymotrypsin inhibitor-like	195.85	1493.56	0.13	1.73E−02
	ACF57858	Chymotrypsin inhibitor precursor	233.56	3678.45	0.06	1.37E−03
Protein modification	B7PWF5	Heat shock protein 20.5, putative	113.92	5.08	22.43	4.59E−02
Protein modification	B7PAR6	Heat shock protein, putative	222.48	1285.43	0.17	2.46E−03
Signal transduction	XP_021001474	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	158.76	8.41	18.89	7.25E−03
Transporter/receptors	AGQ57038	Vitellogenin receptor	651.87	25.70	25.37	3.94E−06
	XP_015908566	Low-density lipoprotein receptor-related protein 2	107.78	53.93	2.00	1.88E−03
	XP_018014210	Very low-density lipoprotein receptor-like	783.98	924.47	0.85	1.22E−02
	B7PL51	ML domain-containing protein, putative	93.47	491.13	0.19	4.30E−04
Unknown function	XP_023240426	Synaptogenesis protein syg-2-like	137.70	1.41	97.65	3.88E−03
	ACB70374	Putative salivary secreted protein, partial	1704.00	91.42	18.64	2.08E−02
	ABI52697	7 cysteine domain	213.20	134.32	1.59	1.96E−03
	ABR23379	Salivary basic tailless protein	1124.06	1987.85	0.57	9.02E−05
	XP_023213207	Transmembrane protein 241-like	70.75	178.42	0.40	9.99E−03
	AAS94230	Unknown secreted protein PK-26 precursor	13,381.20	43,089.64	0.31	2.25E−02
	ABR23361	Acid tail salivary protein	14.64	53.69	0.27	3.47E−03
	B7PLB9	Secreted protein, putative	502.91	4091.22	0.12	6.10E−04
	ACB70369	Acid tail salivary protein	11.20	151.34	0.07	9.36E−05
	XP_022900755	S-phase kinase-associated protein 1	189.20	5274.83	0.04	2.50E−04

^aP < 0.05

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