Insecticidal efficacy against Phlebotomus perniciosus in dogs treated orally with fluralaner in two different parallel-group, negative-control, random and masked trials

Table 2 Survival of blood-fed Phlebotomus perniciosus female sand flies and calculated insecticidal efficacy following feeding on fluralaner treated or non-treated dogs

Days following treatment	Survival assessment time point (h)	Trial 1			Trial 2
		Mean survival proportion^a (%)		Insecticidal efficacy^b (%)	Mean survival proportion^a (%)		Insecticidal efficacy^b (%)
		Untreated group	Fluralaner-treated group	Insecticidal efficacy^b (%)	Untreated group	Fluralaner-treated group	Insecticidal efficacy^b (%)
1	6	ND	ND		99.4	58.1	41.6*
	24	89.2	0.0	100***	97.4	1.8	98.1***
	48	76.0	–	–	95.9	1.8	98.1***
	72	67.8	–	–	89.8	1.8	98.0***
	96	61.1	–	–	73.0	1.1	98.5***
28	6	96.9	62.6	35.5*	100	94.4	5.6
	24	96.9	0.0	100***	87.3	0.0	100***
	48	93.5	–	–	61.1	–	–
	72	89.6	–	–	33.9	–	–
	96	80.6	–	–	19.2	–	–
56	6	93.8	89.0	5.1	100	98.1	1.9
	24	81.9	35.8	56.3	100	90.6	9.4
	48	66.8	13.7	79.5**	70.3	16.7	76.3**
	72	58.9	3.4	94.2***	64.1	11.9	81.4**
	96	42.0	0.4	99.1**	61.0	8.6	85.9***
84	6	100	91.7	8.3	100	100	0.0
	24	100	63.6	36.4	94.5	98.2	0.0
	48	92.7	39.7	57.2*	80.8	82.9	0.0
	72	81.7	37.1	54.6*	57.3	71.1	0.0
	96	66.4	31.4	52.7*	46.8	56.6	0.0

ND, Not done
*, **, ***P-value as calculated by the comparison of survival proportions between treated and control groups: Significant at: *< 0.05;,**< 0.01; ***< 0.001
^aSurvival proportion of blood-fed P. perniciosus female sand flies per dog (%) = [(live blood-fed females/all blood-fed females) × 100]
^bInsecticidal efficacy (%) = 100 × [(mean proportion of live fed females in control group − mean proportion of live fed females in fluralaner-treated group)/mean proportion of live fed females in control group]

ISSN: 1756-3305