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Fig. 1 | Parasites & Vectors

Fig. 1

From: Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

Fig. 1

Summary of the analysis and selection of bacteria from vector microbiota for cultivation and genetic modification in vitro. The microorganism (A) is genetically modified by the insertion of an exogenous gene in a plasmid (B) or directly into the bacterial chromosome (C). The transgenic bacteria are offered to adult insects through an attractant bait. In the insect's digestive tract, the genetically modified microorganism expresses a peptide capable of interrupting the transmission of the parasite or a dsRNA that can silence genes in the parasite or the vector, if these are sensitive to RNA interference, thereby blocking parasite development. Abbreviations: dsRNA, Double-stranded RNA

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