Skip to main content

Table 1 Expression and function of Eimeria proteins

From: Eimeria proteins: order amidst disorder

Speceis

Stages/organelles

Protein

Functions

References

E. nieschulzi

Oocyst

OWP13; cystein-rich

Transglutaminase activity*

[50]

Oocyst wall formation

E. acevulina

Oocyst, sporozoite

Apartyl proteinase; 43 kDa

Antigen

[153]

E. tenalla

UO

LDH, enolase, b-tubulin, kinase Hsp70

Immunogenes, metabolism

[134]

E. tenella

Sporoblast, sporocyst SO, sporozoite

Hsp70, 70 kDa

Stress adaptation

[136]

E. tenella

Oocyst

Hsp70

SC component, chromosome, pairing, disjuction and recombination

[141]

E. brunetti

Oocysts, Sz

MIC2

Immunogenic

[157]

E. tenella

SO, Sz, Mz, Tz, schizonts

Protein disulphide isomerase (PDI)

Sporulation, adhesion, invasion and development

[70]

E. tenella

SO, Sz, Mz

ESP

Rhoptry, PVM, oocyst microgamete development

[75]

E. necatrix

UO, SO, sporocyst wall

gam 22

Immunogene

[53]

E. tenella

Sporocyst, SO

MOP1 (28.7 kDa)

Unknown

[72]

 

Gametocytep, Sz

MOP2 (30.1 kDa

E. stiedai

UO, SO, Mz

MIC 1 (25.89 kDa)

Immunogenic

[89]

 

Gametocyte

MIC 3 (32.39 kDa)

Antigen

E. tenella

OU, SO,Sz, Mz, Tz schizont

ECP (25.4 kDa)

Invasion, development merogony

[110]

E. tenella

UO, SO

AMA1

Invasion and development

[94]

E. tenella

2nd merozoites, Sz Sz. Mz, UO, SO

SZ-1; 19 kDa, profiling-like

Parasite maintenance

[63]

E. nieschulzi

Sporoblast/sporocyst SO, circumplasm

OWP2,6

Sporocyst wall formation

[26]

E. tenella

Gametocyte, Mz

Cathepsin-L-like peptidase

Endogenous parasite development, immunogenp

[118]

 

Sz and UO

 
   

Initiate sporulationP

E. tenella

Sz, Mz, early oocyst, late oocysts

SAGs

Antigen

[71]

RONs

Protein synthesis, antigen

MIC8

Metabolism

E. tenella

Mz

RON2, AMA2& RON5 AMA1& RON4

Cell communication, invasion, antigen

[71]

E. maxima

Oocyst

wp29 and wp33

Oocyst wall formation oocyst wall hardening

[66]

E. maxima

SO, Sz, Mz

ESP; 30 kDa

Interaction with host structural PVM and microgamete protein

[75]

E. tenella

UO, SO, Sz, Mz

ECP 25.4 kDa

PVM formation

[110]

E. maxima

UO, SO, Sz, Mz

 

Antigen

[112, 121, 122]

E. acevulina

UO, SO, Sz, Mz

 

E. acevulina

SO, Sz

Eimepsin/aspartyl proteinase 43-kDa

E. maxima

SO, Sz

E. falciformis

SO, Sz

 

E. tenella

SO, Sz

 

E. tenella

Sporocysts, Sz, Mz

ESP (27.9- > 34 kDa)

Sporozoite invasion

[92]

E.acevulina

Sz Mz

MIC 3 (93.04 kDa)

Immunogene

[90]

E. tenella

Sporocyst

Sporocyst wall protein 1 Tyrosine-rich

Sporocyst wall formation

[158]

E. acevulina

Sz, Mz

MIC 5 (12.18 kDa)

Antigenic

[96]

 

Sz, Mz

MIC 2

Immunogenic,

[41]

E. tenella

Sz, Mz, 1st schizogony

Hsp90

Host cell invasion, stress intracellular growthp

[139]

E. tenella

Sz

SO7* SAG 13, 14

Invasion antigenic*

[112]

E. tenella

Sz, im/mature schizonts

CHP559

Invasion

[33]

E. acevulina

Sz conoid

*EF-1α-associated protein

Cytoskeleton, growth, motility, protein turnover, signal transduction, transhydrogenase

[42]

E. tenella

Sz apicoplast

38 kDa Malonyl-CoA acyl-carrier protein transacylase

Fatty acid biosynthesis enzyme, drug target*

[150]

E. tenella

Sz, 2ndgeneration Mz

Hsp20.4

Sporulation, survival response to stress

[138]

E. tenella

Sz

ROP1 (73 kDa) with NTE

Inhibit apoptosis, arrest of G0/G1 cell cycle

[54]

E. tenella

Sz, Tz, schizont

MIC2 (50 kDa)

Unknown

[99]

E. bovis

Sz, Mz

hsp70-like antigens

Antigenic, parasite survival*

[137]

E. mitis

Sz

MIC3; 124 kDa

Antigenic, confers immunity

[98]

E. tenella

Sz

MIC 3

Development, invasion

[112]

E. stiedai

Sz

100 kDa antigen

Host cell penetration

[109]

E. maxima

Sz

IMP1

Immunogenenic

[150]

E. acevulina

Sz

p160/p240;19 kDa

(Conserved) antigen

[142]

E. tenella

Sz

 

(Conserved) antigen

 

E. maxima

Sz

 

(Conserved) antigen

 

E. falciformis

Sz

 

(Conserved) antigen

 

E. tenella

2nd gen. Mz

14-3-3, subtilase lactacte

Immunogenic

[99]

E. tenella

Gametocytes, inner oocyst wall

WFB 2, Gam 22

Oocyst structural component

[57]

E. maxima

Gametocytes

Gam 52 and 86

Oocyst wall formation

[64]

E. tenella

Sz, Mz and SO

MIC8;100 kDa

Invasion, adhesin immunogene

[85]

E. acevulina

E. maxima

WFB, macrogametocytes

gam56, 82 (52.45 and 62.45 kDa)

Antigenic, gametocyte differentiation

[73]

E. tenella

Sporozoite

EF-2, 14-3-3, transhydrogenase

Common immunogenic antigens

[108]

E. acevulina

E. maxima

E. tenella

Sz, Mz, PVM, immature schizont

19 kDa,175aa;serine/threonine protein phosphatase

Drug resistance, invasion*

[84]

E. tenella

Sz, schizont, PVM

MIC1; Transmembrane with epitope 1 &CTR

PV formation, parasite development

[85]

E. tenella

Sz, Mz, apicoplast macrogametocyte

35 kDa Enoyl reductase

Type II fatty acid biosynthesis

[40]

E. tenella

Sporozoite

Enoyl reductase

Drug target*

[151]

E. tenella

UO, SO, Sz

Serpin (45 kDa) serine protease inhibitor

Parasite survival invasion*

[118]

E. acevulina

Oocyst,Sz, Mz

Serpin; 48/55 kDa

Invasion development*

[94]

E. tenella

Sz, 1st & 2nd generation Mz, gametocyte, UO

MIC2;35.07 kDa

Invasion antigen

[58]

342aa acidic protein

 

E. tenella

Gametocyte, UO, SO

HOWP1; 40, 30 & 23 kDa

Vaccine*

[26]

  1. SC synaptonema complex, UO unsporulated oocyst, SO sporulated oocyst, Sz sporozoite, Mz merozoite, Tz trophozoite, *speculative protein/function, NTE N-terminal extension, Ef-2 elongation factor 2