Speceis | Stages/organelles | Protein | Functions | References |
---|---|---|---|---|
E. nieschulzi | Oocyst | OWP13; cystein-rich | Transglutaminase activity* | [50] |
Oocyst wall formation | ||||
E. acevulina | Oocyst, sporozoite | Apartyl proteinase; 43Â kDa | Antigen | [153] |
E. tenalla | UO | LDH, enolase, b-tubulin, kinase Hsp70 | Immunogenes, metabolism | [134] |
E. tenella | Sporoblast, sporocyst SO, sporozoite | Hsp70, 70Â kDa | Stress adaptation | [136] |
E. tenella | Oocyst | Hsp70 | SC component, chromosome, pairing, disjuction and recombination | [141] |
E. brunetti | Oocysts, Sz | MIC2 | Immunogenic | [157] |
E. tenella | SO, Sz, Mz, Tz, schizonts | Protein disulphide isomerase (PDI) | Sporulation, adhesion, invasion and development | [70] |
E. tenella | SO, Sz, Mz | ESP | Rhoptry, PVM, oocyst microgamete development | [75] |
E. necatrix | UO, SO, sporocyst wall | gam 22 | Immunogene | [53] |
E. tenella | Sporocyst, SO | MOP1 (28.7Â kDa) | Unknown | [72] |
 | Gametocytep, Sz | MOP2 (30.1 kDa | ||
E. stiedai | UO, SO, Mz | MIC 1 (25.89Â kDa) | Immunogenic | [89] |
 | Gametocyte | MIC 3 (32.39 kDa) | Antigen | |
E. tenella | OU, SO,Sz, Mz, Tz schizont | ECP (25.4Â kDa) | Invasion, development merogony | [110] |
E. tenella | UO, SO | AMA1 | Invasion and development | [94] |
E. tenella | 2nd merozoites, Sz Sz. Mz, UO, SO | SZ-1; 19Â kDa, profiling-like | Parasite maintenance | [63] |
E. nieschulzi | Sporoblast/sporocyst SO, circumplasm | OWP2,6 | Sporocyst wall formation | [26] |
E. tenella | Gametocyte, Mz | Cathepsin-L-like peptidase | Endogenous parasite development, immunogenp | [118] |
 | Sz and UO |  | ||
 |  |  | Initiate sporulationP | |
E. tenella | Sz, Mz, early oocyst, late oocysts | SAGs | Antigen | [71] |
RONs | Protein synthesis, antigen | |||
MIC8 | Metabolism | |||
E. tenella | Mz | RON2, AMA2& RON5 AMA1& RON4 | Cell communication, invasion, antigen | [71] |
E. maxima | Oocyst | wp29 and wp33 | Oocyst wall formation oocyst wall hardening | [66] |
E. maxima | SO, Sz, Mz | ESP; 30Â kDa | Interaction with host structural PVM and microgamete protein | [75] |
E. tenella | UO, SO, Sz, Mz | ECP 25.4Â kDa | PVM formation | [110] |
E. maxima | UO, SO, Sz, Mz | Â | Antigen | |
E. acevulina | UO, SO, Sz, Mz | Â | ||
E. acevulina | SO, Sz | Eimepsin/aspartyl proteinase 43-kDa | ||
E. maxima | SO, Sz | |||
E. falciformis | SO, Sz | Â | ||
E. tenella | SO, Sz | Â | ||
E. tenella | Sporocysts, Sz, Mz | ESP (27.9- > 34 kDa) | Sporozoite invasion | [92] |
E.acevulina | Sz Mz | MIC 3 (93.04Â kDa) | Immunogene | [90] |
E. tenella | Sporocyst | Sporocyst wall protein 1 Tyrosine-rich | Sporocyst wall formation | [158] |
E. acevulina | Sz, Mz | MIC 5 (12.18Â kDa) | Antigenic | [96] |
 | Sz, Mz | MIC 2 | Immunogenic, | [41] |
E. tenella | Sz, Mz, 1st schizogony | Hsp90 | Host cell invasion, stress intracellular growthp | [139] |
E. tenella | Sz | SO7* SAG 13, 14 | Invasion antigenic* | [112] |
E. tenella | Sz, im/mature schizonts | CHP559 | Invasion | [33] |
E. acevulina | Sz conoid | *EF-1α-associated protein | Cytoskeleton, growth, motility, protein turnover, signal transduction, transhydrogenase | [42] |
E. tenella | Sz apicoplast | 38Â kDa Malonyl-CoA acyl-carrier protein transacylase | Fatty acid biosynthesis enzyme, drug target* | [150] |
E. tenella | Sz, 2ndgeneration Mz | Hsp20.4 | Sporulation, survival response to stress | [138] |
E. tenella | Sz | ROP1 (73Â kDa) with NTE | Inhibit apoptosis, arrest of G0/G1 cell cycle | [54] |
E. tenella | Sz, Tz, schizont | MIC2 (50Â kDa) | Unknown | [99] |
E. bovis | Sz, Mz | hsp70-like antigens | Antigenic, parasite survival* | [137] |
E. mitis | Sz | MIC3; 124Â kDa | Antigenic, confers immunity | [98] |
E. tenella | Sz | MIC 3 | Development, invasion | [112] |
E. stiedai | Sz | 100Â kDa antigen | Host cell penetration | [109] |
E. maxima | Sz | IMP1 | Immunogenenic | [150] |
E. acevulina | Sz | p160/p240;19Â kDa | (Conserved) antigen | [142] |
E. tenella | Sz | Â | (Conserved) antigen | Â |
E. maxima | Sz | Â | (Conserved) antigen | Â |
E. falciformis | Sz | Â | (Conserved) antigen | Â |
E. tenella | 2nd gen. Mz | 14-3-3, subtilase lactacte | Immunogenic | [99] |
E. tenella | Gametocytes, inner oocyst wall | WFB 2, Gam 22 | Oocyst structural component | [57] |
E. maxima | Gametocytes | Gam 52 and 86 | Oocyst wall formation | [64] |
E. tenella | Sz, Mz and SO | MIC8;100Â kDa | Invasion, adhesin immunogene | [85] |
E. acevulina | ||||
E. maxima | WFB, macrogametocytes | gam56, 82 (52.45 and 62.45Â kDa) | Antigenic, gametocyte differentiation | [73] |
E. tenella | Sporozoite | EF-2, 14-3-3, transhydrogenase | Common immunogenic antigens | [108] |
E. acevulina | ||||
E. maxima | ||||
E. tenella | Sz, Mz, PVM, immature schizont | 19Â kDa,175aa;serine/threonine protein phosphatase | Drug resistance, invasion* | [84] |
E. tenella | Sz, schizont, PVM | MIC1; Transmembrane with epitope 1 &CTR | PV formation, parasite development | [85] |
E. tenella | Sz, Mz, apicoplast macrogametocyte | 35Â kDa Enoyl reductase | Type II fatty acid biosynthesis | [40] |
E. tenella | Sporozoite | Enoyl reductase | Drug target* | [151] |
E. tenella | UO, SO, Sz | Serpin (45Â kDa) serine protease inhibitor | Parasite survival invasion* | [118] |
E. acevulina | Oocyst,Sz, Mz | Serpin; 48/55Â kDa | Invasion development* | [94] |
E. tenella | Sz, 1st & 2nd generation Mz, gametocyte, UO | MIC2;35.07Â kDa | Invasion antigen | [58] |
342aa acidic protein | Â | |||
E. tenella | Gametocyte, UO, SO | HOWP1; 40, 30 & 23Â kDa | Vaccine* | [26] |