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Table 1 Efficacy of Simparica Trio® against ML-resistant heartworms compared to Heartgard® Plus or Interceptor® Plus: study design

From: Preventive efficacy of six monthly oral doses of Simparica Trio®, Heartgard® Plus, and Interceptor® Plus against a macrocyclic lactone-resistant strain (ZoeLA) of heartworm (Dirofilaria immitis) in dogs

Group

Treatment

Oral dosageb

No. of dogs

Day of L3

D. immitis inoculationa

Days of treatment

Days of blood microfilariae and adult D. immitis antigen testing

Day of necropsy and adult D. immitis worm recovery

T01

Placebo control

na

6

-30

0, 30, 60, 90, 120, 150

-63, -35, 60, 180, 210, 236

241

T02

Simparica Trio

Label dosing

6

T03

Heartgard Plus

Label dosing

6

T04

Interceptor Plus

Label dosing

6

  1. aEach dog was inoculated with 50 infective L3 of D. immitis (ZoeLA isolate)
  2. bSimparica Trio (minimum of 24 µg/kg moxidectin + 1.2 mg/kg sarolaner + 5 mg/kg pyrantel), Heartgard Plus (minimum of 6 µg/kg ivermectin + 5 mg/kg pyrantel) and Interceptor Plus (minimum of 500 µg/kg milbemycin) oxime + 5 mg/kg praziquantel) administered at their approved dosages according to their commercial label directions