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Table 1 Efficacy of Simparica Trio® against ML-resistant heartworms compared to Heartgard® Plus or Interceptor® Plus: study design

From: Preventive efficacy of six monthly oral doses of Simparica Trio®, Heartgard® Plus, and Interceptor® Plus against a macrocyclic lactone-resistant strain (ZoeLA) of heartworm (Dirofilaria immitis) in dogs

Group Treatment Oral dosageb No. of dogs Day of L3
D. immitis inoculationa
Days of treatment Days of blood microfilariae and adult D. immitis antigen testing Day of necropsy and adult D. immitis worm recovery
T01 Placebo control na 6 -30 0, 30, 60, 90, 120, 150 -63, -35, 60, 180, 210, 236 241
T02 Simparica Trio Label dosing 6
T03 Heartgard Plus Label dosing 6
T04 Interceptor Plus Label dosing 6
  1. aEach dog was inoculated with 50 infective L3 of D. immitis (ZoeLA isolate)
  2. bSimparica Trio (minimum of 24 µg/kg moxidectin + 1.2 mg/kg sarolaner + 5 mg/kg pyrantel), Heartgard Plus (minimum of 6 µg/kg ivermectin + 5 mg/kg pyrantel) and Interceptor Plus (minimum of 500 µg/kg milbemycin) oxime + 5 mg/kg praziquantel) administered at their approved dosages according to their commercial label directions